N'-[(E)-[4-[bis(2-chloroethyl)amino]phenyl]methylideneamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]propanediamide

Base Information

• Chemical Name: N'-[(E)-[4-[bis(2-chloroethyl)amino]phenyl]methylideneamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]propanediamide
• CAS No.: 18612-37-8
• Molecular Formula: C₂₄H₂₅Cl₂N₅O₂S
• Molecular Weight: 518.467
• NSC Number: 82373
• Mol file: 18612-37-8.mol

Synonyms:NSC82373;18612-37-8;NSC-82373

Chemical Property of N'-[(E)-[4-[bis(2-chloroethyl)amino]phenyl]methylideneamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]propanediamide

Chemical Property:

• Density: 1.33g/cm³
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 517.1106016
• Heavy Atom Count: 34
• Complexity: 664

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)CC(=O)NN=CC3=CC=C(C=C3)N(CCCl)CCCl
• Isomeric SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)CC(=O)N/N=C/C3=CC=C(C=C3)N(CCCl)CCCl

Technology Process of N'-[(E)-[4-[bis(2-chloroethyl)amino]phenyl]methylideneamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]propanediamide

There total 1 articles about N'-[(E)-[4-[bis(2-chloroethyl)amino]phenyl]methylideneamino]-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]propanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(bis(2-chloroethyl)amino)benzaldehyde (1208-03-3) + N-(4-p-tolyl-thiazol-2-yl)-malonamic acid hydrazide (18612-31-2) → N-(4-p-tolyl-thiazol-2-yl)-malonamic acid {4-[bis-(2-chloro-ethyl)-amino]-benzylidene}-hydrazide (18612-37-8)

Guidance literature:

In ethanol; at 70 ℃;

DOI:10.1021/jm00307a037

upstream raw materials:

4-(bis(2-chloroethyl)amino)benzaldehyde

N-(4-p-tolyl-thiazol-2-yl)-malonamic acid hydrazide

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