1H-Pyrazole-5-carboxylic acid, 3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl)meth yl]-

Base Information

Chemical Name:1H-Pyrazole-5-carboxylic acid, 3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl)meth yl]-
CAS No.:650609-89-5
Molecular Formula:C19H25N3O7
Molecular Weight:407.423
Hs Code.:

Synonyms:2-(4-Methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid;2-(4-methoxybenzyl)-5-{2-[2-(2-methoxyethoxy)ethoxy]acetylamino}-2H-pyrazole-3-carboxylic acid;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole-5-carboxylic acid, 3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl)meth yl]-

Chemical Property:

Melting Point:96 °C
Boiling Point:665.8±55.0 °C(Predicted)
PSA：121.14000
Density:1.28±0.1 g/cm3(Predicted)
LogP:1.32930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxylic acid, 3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl)meth yl]-

There total 4 articles about 1H-Pyrazole-5-carboxylic acid, 3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl)meth yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 650609-88-4
2-(4-methoxybenzyl)-5-{2-[2-(2-methoxyethoxy)ethoxy]acetylamino}-2H-pyrazole-3-carboxylic acid methyl ester

: 650609-89-5
2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; for 16h;
DOI:10.1055/s-2003-41031

Reference yield:

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 650609-89-5
2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-chloro-3-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂

2: aq. LiOH / methanol; tetrahydrofuran

With lithium hydroxide; 1-chloro-3-methylpyridinium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja045558b

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 650609-89-5
2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 18 h / 50 °C

2: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

3: 53 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium chloride / CH₂Cl₂ / 18 h / 20 °C

4: 78 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h

With lithium hydroxide; hydrogen; 1-methyl-2-chloropyridinium chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-41031