1H-Pyrazole-5-carboxylic acid, 3-[[[3-(acetylamino)-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl]carbon yl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

Base Information

Chemical Name:1H-Pyrazole-5-carboxylic acid, 3-[[[3-(acetylamino)-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl]carbon yl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester
CAS No.:650610-02-9
Molecular Formula:C27H28N6O6
Molecular Weight:532.556
Hs Code.:

1H-Pyrazole-5-carboxylic acid,
3-[[[3-(acetylamino)-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl]carbon
yl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxylic acid, 3-[[[3-(acetylamino)-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl]carbon yl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Pyrazole-5-carboxylic acid, 3-[[[3-(acetylamino)-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl]carbon yl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

There total 6 articles about 1H-Pyrazole-5-carboxylic acid, 3-[[[3-(acetylamino)-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-5-yl]carbon yl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 650610-00-7
5-acetylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid

: 650610-02-9
5-{[5-acetylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1055/s-2003-41031

Reference yield:

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 650610-02-9
5-{[5-acetylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine / CH₂Cl₂

2: aq. LiOH / methanol; tetrahydrofuran

3: 46 percent / 2-chloro-1-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂ / 20 °C

With lithium hydroxide; 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja045558b

Reference yield:

: 650609-98-6
5-acetylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 650610-02-9
5-{[5-acetylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / methanol; tetrahydrofuran

2: 46 percent / 2-chloro-1-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂ / 20 °C

With lithium hydroxide; 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja045558b