(3R,4S,5S)-3-hydroxy-5-[(R)-hydroxy-phenyl-methyl]-1-methyl-4-phenyl-p yrrolidin-2-one

Base Information

Chemical Name:(3R,4S,5S)-3-hydroxy-5-[(R)-hydroxy-phenyl-methyl]-1-methyl-4-phenyl-p yrrolidin-2-one
CAS No.:109905-95-5
Molecular Formula:C18H19NO3
Molecular Weight:297.354
Hs Code.:
Mol file:109905-95-5.mol

Synonyms:2-Pyrrolidinone,3-hydroxy-5-(hydroxyphenylmethyl)-1-methyl-4-phenyl;(3R,4S,5S)-3-HYDROXY-5-[(R)-HYDROXY-PHENYL-METHYL]-1-METHYL-4-PHENYL-PYRROLIDIN-2-ONE;

Suppliers and Price of (3R,4S,5S)-3-hydroxy-5-[(R)-hydroxy-phenyl-methyl]-1-methyl-4-phenyl-p yrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (3R,4S,5S)-3-hydroxy-5-[(R)-hydroxy-phenyl-methyl]-1-methyl-4-phenyl-p yrrolidin-2-one

Chemical Property:

Boiling Point:531.7°Cat760mmHg
Flash Point:275.3°C
PSA：60.77000
Density:1.27g/cm³
LogP:1.64320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R,4S,5S)-3-hydroxy-5-[(R)-hydroxy-phenyl-methyl]-1-methyl-4-phenyl-p yrrolidin-2-one

There total 19 articles about (3R,4S,5S)-3-hydroxy-5-[(R)-hydroxy-phenyl-methyl]-1-methyl-4-phenyl-p yrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (+/-)‐clausenamidone

: 103541-15-7,104973-66-2,109905-95-5,110414-73-8,114528-76-6,114528-82-4,119616-14-7,126720-48-7,134052-81-6,134052-82-7
(+/-)-clausenamide

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1039/b901965k

Reference yield: 83.0%

: 130273-48-2
(3R,4S,5S)-clausenamidone

: 109905-95-5
(±)-(3R,4S,5S,6R)-clausenamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;
DOI:10.1039/a801450g

Reference yield:

: phenylmagnesium bromide

: 103541-15-7,104973-66-2,109905-95-5,110414-73-8,114528-76-6,114528-82-4,119616-14-7,126720-48-7,134052-81-6,134052-82-7
(+/-)-clausenamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 1 h / 0 - 5 °C

2: trifluoroacetic anhydride, DMSO / CH₂Cl₂ / 1.5 h / -60 °C

3: LiB(Et)3H / tetrahydrofuran / 1 h / 0 °C

4: 1.) LDA, HMPT, 2.) P(OEt)3, O₂ / 1.) THF, hexane, from -70 to -60 deg C, 1 h, 2.) THF, hexane, -70 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; lithium triethylborohydride; dimethyl sulfoxide; trifluoroacetic anhydride; lithium diisopropyl amide; triethyl phosphite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00228a037