5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl] amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl] amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-
CAS No.:651059-37-9
Molecular Formula:C35H50N4O11S
Molecular Weight:734.868
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl]
amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-,
(4-methoxyphenyl)methyl ester, (6R,7R)-

Synonyms:

Suppliers and Price of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl] amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl] amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl] amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

There total 10 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(3S)-3-[[(4R)-4-(acetylamino)-5-(1,1-dimethylethoxy)-1,5-dioxopentyl] amino]-4-hydroxybutyl]-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 651059-36-8
(6R,7R)-3-[(E)-(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-hydroxy-but-1-enyl]-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 651059-37-9
(6R,7R)-3-[(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-hydroxy-butyl]-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/ja038445l

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 651059-37-9
(6R,7R)-3-[(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-hydroxy-butyl]-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 51 percent / N-trimethylsilylacetamide / CH₂Cl₂ / 20 °C

2.1: 4.5 g / NaI / butan-2-one / 20 °C

3.1: 68 percent / acetonitrile / 20 °C

4.1: potassium trimethylsilanoate / acetonitrile; CHCl₃ / 0.5 h / cooling

4.2: 77 percent / acetonitrile; CHCl₃; CH₂Cl₂ / 3 h / 20 °C

5.1: 54 percent / H₂; acetic acid / Pd/C / methanol / 3 h

6.1: 5.6 g / triethylamine / CH₂Cl₂ / 3 h / -78 - 20 °C

7.1: 46 percent / H₂ / Pd/C / tetrahydrofuran

With potassium trimethylsilonate; hydrogen; acetic acid; triethylamine; N-Trimethylsilylacetamide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetonitrile; butanone;
DOI:10.1021/ja038445l

Reference yield:

: 106773-36-8
4-methoxybenzyl-7-amino-3-chloromethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

: 651059-37-9
(6R,7R)-3-[(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-hydroxy-butyl]-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 51 percent / N-trimethylsilylacetamide / CH₂Cl₂ / 20 °C

2.1: 4.5 g / NaI / butan-2-one / 20 °C

3.1: 68 percent / acetonitrile / 20 °C

4.1: potassium trimethylsilanoate / acetonitrile; CHCl₃ / 0.5 h / cooling

4.2: 77 percent / acetonitrile; CHCl₃; CH₂Cl₂ / 3 h / 20 °C

5.1: 54 percent / H₂; acetic acid / Pd/C / methanol / 3 h

6.1: 5.6 g / triethylamine / CH₂Cl₂ / 3 h / -78 - 20 °C

7.1: 46 percent / H₂ / Pd/C / tetrahydrofuran

With potassium trimethylsilonate; hydrogen; acetic acid; triethylamine; N-Trimethylsilylacetamide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetonitrile; butanone;
DOI:10.1021/ja038445l