Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester

Base Information

Chemical Name:Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester
CAS No.:651312-15-1
Molecular Formula:C18H19F2NO2
Molecular Weight:319.351
Hs Code.:
DSSTox Substance ID:DTXSID90459240
Nikkaji Number:J1.977.181D
Wikidata:Q82282958

Synonyms:651312-15-1;Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester;AORCZWNXHQYMLI-UHFFFAOYSA-;DTXSID90459240;AORCZWNXHQYMLI-UHFFFAOYSA-N;3-(Benzhydrylamino)-2,2-difluoropropionic acid ethyl ester;InChI=1/C18H19F2NO2/c1-2-23-17(22)18(19,20)13-21-16(14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12,16,21H,2,13H2,1H3

Suppliers and Price of Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:319.13838517
Heavy Atom Count:23
Complexity:346

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CNC(C1=CC=CC=C1)C2=CC=CC=C2)(F)F

Technology Process of Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester

There total 2 articles about Propanoic acid, 3-[(diphenylmethyl)amino]-2,2-difluoro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 651312-14-0
N-(benzhydryl)-1H-benzotriazolyl-1-methylamine

: 651312-15-1
ethyl 3-(benzhydrylamino)-2,2-difluoropropanoate

Guidance literature:: Ethyl bromodifluoroacetate; With chloro-trimethyl-silane; In tetrahydrofuran; for 0.416667h;

N-(benzhydryl)-1H-benzotriazolyl-1-methylamine; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1055/s-2003-42415

Reference yield:

: 91-00-9
Benzhydrylamine

: 651312-15-1
ethyl 3-(benzhydrylamino)-2,2-difluoropropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / methanol / 20 °C

2.1: TMSCl / tetrahydrofuran / 0.42 h

2.2: 86 percent / tetrahydrofuran / 3 h / 25 °C

With chloro-trimethyl-silane; In tetrahydrofuran; methanol;
DOI:10.1055/s-2003-42415