1(2H)-Pyridinecarboxylic acid, 3-fluoro-5,6-dihydro-4-phenyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 3-fluoro-5,6-dihydro-4-phenyl-, 1,1-dimethylethyl ester
CAS No.:651321-26-5
Molecular Formula:C16H20FNO2
Molecular Weight:277.33400
Hs Code.:

Synonyms:5-Fluoro-4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1(2H)-Pyridinecarboxylic acid, 3-fluoro-5,6-dihydro-4-phenyl-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3-fluoro-5,6-dihydro-4-phenyl-, 1,1-dimethylethyl ester

Chemical Property:

PSA：29.54000
LogP:3.94590

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1(2H)-Pyridinecarboxylic acid, 3-fluoro-5,6-dihydro-4-phenyl-, 1,1-dimethylethyl ester

There total 3 articles about 1(2H)-Pyridinecarboxylic acid, 3-fluoro-5,6-dihydro-4-phenyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 3-fluoro-4-hydroxy-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester

: 651321-26-5
3-fluoro-4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With pyridine; trichlorophosphate; at 0 ℃; for 24h;
DOI:10.1016/j.bmc.2003.08.002

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 651321-26-5
3-fluoro-4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran / 1 h / 0 °C

1.2: 46 percent / tetrahydrofuran / 4 h / 20 °C

2.1: 10 percent / POCl₃; pyridine / 24 h / 0 °C

With pyridine; magnesium; trichlorophosphate; In tetrahydrofuran; 1.2: Grignard reaction;
DOI:10.1016/j.bmc.2003.08.002

Reference yield:

: 211108-50-8
tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

: 651321-26-5
3-fluoro-4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran / 1 h / 0 °C

1.2: 46 percent / tetrahydrofuran / 4 h / 20 °C

2.1: 10 percent / POCl₃; pyridine / 24 h / 0 °C

With pyridine; magnesium; trichlorophosphate; In tetrahydrofuran; 1.2: Grignard reaction;
DOI:10.1016/j.bmc.2003.08.002