1-Pyrrolidinecarboxylic acid, 2-[10-oxo-13-(phenylmethoxy)tridecyl]-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[10-oxo-13-(phenylmethoxy)tridecyl]-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-
CAS No.:651321-50-5
Molecular Formula:C51H67NO7
Molecular Weight:806.095
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[10-oxo-13-(phenylmethoxy)tridecyl]-3,4-bis(phenylmethoxy)-5-[(phen
ylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[10-oxo-13-(phenylmethoxy)tridecyl]-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[10-oxo-13-(phenylmethoxy)tridecyl]-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

There total 19 articles about 1-Pyrrolidinecarboxylic acid, 2-[10-oxo-13-(phenylmethoxy)tridecyl]-3,4-bis(phenylmethoxy)-5-[(phen ylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 651321-49-2
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-[1-(phenylmethyloxy)-4-hydroxytridecan-13-yl]pyrrolidine

: 651321-50-5
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-[1-(phenylmethyloxy)-4-oxotridecan-13-yl]pyrrolidine

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1081/CAR-120026470

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 651321-50-5
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-[1-(phenylmethyloxy)-4-oxotridecan-13-yl]pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / Et₃N / tetrahydrofuran / 0.03 h / 0 - 20 °C

2: Et₃N / CH₂Cl₂ / 1.58 h / 0 - 20 °C

3: t-BuOK / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

4: K₂OsO₄*2H₂O; NMO / acetone; H₂O / 3 h / 20 °C

5: NaIO₄ / diethyl ether; H₂O / 2 h / 20 °C

6: 70 percent / tetrahydrofuran / 3 h / 20 °C

7: 90 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 0 °C

With potassium osmate(VI); sodium periodate; N-methyl-2-indolinone; potassium tert-butylate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1081/CAR-120026470

Reference yield:

: 138535-75-8
2,3-di-O-benzyl-D-arabinose diethyl dithioacetal

: 651321-50-5
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-[1-(phenylmethyloxy)-4-oxotridecan-13-yl]pyrrolidine

Guidance literature:: Multi-step reaction with 18 steps

1: 87 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: HgO; HgCl₂ / acetone; H₂O / 3 h / 60 °C

3: tetrahydrofuran / 3 h / 20 °C

4: 86 percent / HCl / methanol / 3 h / 0 °C

5: 70 percent / p-TsOH / CH₂Cl₂ / 1 h / -20 - 10 °C

6: CH₂Cl₂ / 1.58 h / 0 - 20 °C

7: 80 percent / NaN₃ / dimethylformamide / 18 h / 60 °C

8: 89 percent / AlCl₃; BH₃*NMe₃ / tetrahydrofuran / 3 h / 0 °C

9: 88 percent / PPh₃; DEAD / tetrahydrofuran / 18 h / 20 °C

10: 85 percent / PPh₃; H₂O / tetrahydrofuran / 4 h / 60 °C

11: 76 percent / NaOH / methanol / 0 - 20 °C

12: 80 percent / Et₃N / tetrahydrofuran / 0.03 h / 0 - 20 °C

13: Et₃N / CH₂Cl₂ / 1.58 h / 0 - 20 °C

14: t-BuOK / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

15: K₂OsO₄*2H₂O; NMO / acetone; H₂O / 3 h / 20 °C

16: NaIO₄ / diethyl ether; H₂O / 2 h / 20 °C

17: 70 percent / tetrahydrofuran / 3 h / 20 °C

18: 90 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 0 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; potassium osmate(VI); sodium periodate; aluminium trichloride; sodium azide; N-methyl-2-indolinone; trimethylamine-borane; potassium tert-butylate; water; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; mercury dichloride; mercury(II) oxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; 3: Grignard addition / 9: Mitsunobu reaction / 10: Staudinger reduction;
DOI:10.1081/CAR-120026470