2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid

Base Information

Chemical Name:2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid
CAS No.:651331-92-9
Molecular Formula:C10H7F5O4
Molecular Weight:286.155
Hs Code.:
UNII:NM6AF3AW9M
DSSTox Substance ID:DTXSID00430848
Wikidata:Q82244576

Synonyms:2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid;UR 1505;UR-1505;UR1505

Suppliers and Price of 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:286.02644951
Heavy Atom Count:19
Complexity:330

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1OCC(C(F)(F)F)(F)F)O)C(=O)O
Recent EU Clinical Trials:DOUBLE-BLIND, RANDOMISED, ACTIVE AND PLACEBO CONTROLLED STUDY TO ASSESS THE CLINICAL EFFICACY, SKIN TOLERABILITY AND PHARMACOLOGICAL ACTIVITY OF A NEW TOPICAL COMPOUND (UR-1505 0.5%, 1% AND 2%) IN PATIENTS WITH MILD TO MODERATE ATOPIC DERMATITIS

Technology Process of 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid

There total 2 articles about 2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 89-86-1
4-hydroxysalicylic acid

: 6401-00-9
2,2,3,3,3-pentafluoropropyl triflate

: 651331-92-9
2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid

Guidance literature:: 4-hydroxysalicylic acid; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

With Trimethyl borate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

2,2,3,3,3-pentafluoropropyl triflate; In DMF (N,N-dimethyl-formamide); at 100 ℃;