2-Ethyl-1-methyl-1h-indole

Base Information

• Chemical Name: 2-Ethyl-1-methyl-1h-indole
• CAS No.: 65136-45-0
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• DSSTox Substance ID: DTXSID60495933
• Nikkaji Number: J587.083F
• Wikidata: Q82344404
• Mol file: 65136-45-0.mol

Synonyms:2-ethyl-1-methyl-1h-indole;2-ETHYL-1-METHYLINDOLE;65136-45-0;SCHEMBL1882418;DTXSID60495933

Chemical Property of 2-Ethyl-1-methyl-1h-indole

Chemical Property:

• PSA: 4.93000
• LogP: 2.74070
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 159.104799419
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC2=CC=CC=C2N1C

Technology Process of 2-Ethyl-1-methyl-1h-indole

There total 24 articles about 2-Ethyl-1-methyl-1h-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-methylindole (603-76-9) + bromobenzene (108-86-1,52753-63-6) + triethyl borane (97-94-9) → 2-ethyl-1-methyl-1H-indole (65136-45-0) + 1-methyl-2-phenyl-1H-indole (3558-24-5)

Guidance literature:

With tert.-butyl lithium; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 3h; Product distribution; Heating;

DOI:10.1039/c39890000135

Reference yield: 80.0%

1-methylindole (603-76-9) + iodobenzene (591-50-4) + triethyl borane (97-94-9) → 2-ethyl-1-methyl-1H-indole (65136-45-0) + 1-methyl-2-phenyl-1H-indole (3558-24-5)

Guidance literature:

With tert.-butyl lithium; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 3h; Product distribution; Heating; other catalysts; other temp./reaction time;

DOI:10.1039/c39890000135

Reference yield: 76.0%

1-methylindole (603-76-9) + triethyl borane (97-94-9) + bromostyrene (103-64-0,1340-14-3) → 2-ethyl-1-methyl-1H-indole (65136-45-0) + 2-(β-styryl)-N-methylindole

Guidance literature:

With tert.-butyl lithium; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 3h; Product distribution; Heating; other catalyst; other temp./reaction time;

DOI:10.1039/c39890000135

upstream raw materials:

3-Bromopyridine

1-methylindole

triethyl borane

2-methyl-1H-indole

Refernces

• 1、 Ishikura,Terashima. "Palladium-catalyzed carbonylative cross-coupling reaction with triethyl(1-methylindol-2-yl)borate: A simple route to 1-methylindol-2-yl ketones". . p. 2634 - 2637. Retrieved 2007/10/02.
• 2、 Ishikura, Minoru,Terashima, Masanao. "VINYLOXYBORANE PROMOTED 1,4-ADDITION OF TRIETHYL(1-METHYLINDOL-2-YL)BORATE TO 2-CYCLOALKENONES". . p. 2091 - 2094. Retrieved 2007/10/02.