1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline

Base Information

Chemical Name:1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline
CAS No.:96719-60-7
Molecular Formula:C22H20BrNO
Molecular Weight:394.311
Hs Code.:
DSSTox Substance ID:DTXSID10914366

Synonyms:1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline;96719-60-7;Isoquinoline, 1,2,3,4-tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenyl-;SCHEMBL19439363;DTXSID10914366;1-(4-BROMOPHENYL)-6-METHOXY-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE;LS-85834

Suppliers and Price of 1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline

Chemical Property:

Vapor Pressure:1.06E-10mmHg at 25°C
Boiling Point:514.7°Cat760mmHg
Flash Point:265.1°C
Density:1.332g/cm³
XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:393.07283
Heavy Atom Count:25
Complexity:416

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(N(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)Br

Technology Process of 1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline

There total 10 articles about 1,2,3,4-Tetrahydro-1-(4-bromophenyl)-6-methoxy-2-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-Bromo-phenyl)-6-methoxy-2-phenyl-3,4-dihydro-isoquinolinium

: 96719-60-7
1-(4-bromophenyl)-6-methoxy-2-phenyl-3,4-dihydro-1H-isoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1021/jm040858p

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 96719-60-7
1-(4-bromophenyl)-6-methoxy-2-phenyl-3,4-dihydro-1H-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

2.1: NaBH₄ / methanol / 20 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm040858p

Reference yield:

: 22246-12-4
6-methoxy-1,2,3,4-tetrahydro-1-oxoisoquinoline

: 96719-60-7
1-(4-bromophenyl)-6-methoxy-2-phenyl-3,4-dihydro-1H-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃; CuI / dimethylformamide / 150 °C

2.1: n-BuLi / hexane; tetrahydrofuran / -78 °C

2.2: tetrahydrofuran; hexane / -78 °C

3.1: NaBH₄ / methanol / 20 °C

With sodium tetrahydroborate; copper(l) iodide; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm040858p