2-Diphenylmethylpiperidine

Base Information

• Chemical Name: 2-Diphenylmethylpiperidine
• CAS No.: 519-74-4
• Molecular Formula: C18H21N
• Molecular Weight: 251.371
• Hs Code.: 2933399090
• European Community (EC) Number: 208-276-6
• UNII: 49UNK1BV8T
• DSSTox Substance ID: DTXSID90897502
• Nikkaji Number: J182.280B
• Wikipedia: Desoxypipradrol
• Wikidata: Q414480
• Mol file: 519-74-4.mol

Synonyms:2-diphenylmethylpiperidine;2-diphenylmethylpiperidine hydrochloride, (R)-isomer;2-diphenylmethylpiperidine hydrochloride, (S)-isomer;2-diphenylmethylpiperidine, (R)-isomer;2-diphenylmethylpiperidine, (S)-isomer;2-DPMP;desoxypipradrol

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2-Diphenylmethylpiperidine

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 1.48E-05mmHg at 25°C
• Melting Point: 65-66 °C
• Refractive Index: 1.567
• Boiling Point: 366.3 °C at 760 mmHg
• PKA: 10.02±0.10(Predicted)
• Flash Point: 181.3 °C
• PSA: 12.03000
• Density: 1.027 g/cm³
• LogP: 4.28940
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 251.167399674
• Heavy Atom Count: 19
• Complexity: 232

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)C(C2=CC=CC=C2)C3=CC=CC=C3
• Uses: 2-Benzhydrylpiperidine can be used as a norepinephrine-dopamine reuptake inhibitor (NDRI). A highly lipophilic molecule lacking polar functional groups that are typically targeted by metabolic enzymes. Useful for application of treating attention-deficit hyperactivity disorder (ADHD) and depression.

Technology Process of 2-Diphenylmethylpiperidine

There total 6 articles about 2-Diphenylmethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Diphenyl-2-pyridylmethan (3678-70-4) → 2-(diphenylmethyl)piperidine (519-74-4)

Guidance literature:

With hydrogen; In isopropyl alcohol; at 160 ℃; for 30h; under 45004.5 Torr; Autoclave;

DOI:10.1002/anie.201803426

Reference yield:

6,6-diphenyl-5-oxo-hexanenitrile (132594-19-5) → 2-(diphenylmethyl)piperidine (519-74-4)

Guidance literature:

With ethanol; nickel; at 100 ℃; under 73550.8 Torr; Hydrogenation;

DOI:10.1002/hlca.19550380318

Reference yield:

→ 2-(diphenylmethyl)piperidine (519-74-4)

Guidance literature:

With pentan-1-ol; sodium;

DOI:10.1002/hlca.19550380318

upstream raw materials:

Diphenyl-2-pyridylmethan

6,6-diphenyl-5-oxo-hexanenitrile

diphenylacetic acid chloride

Diphenylacetonitrile

Downstream raw materials:

1-allyl-2-benzhydryl-piperidine

Refernces