Technology Process of (2R,5S)-2,5-dibutyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine
There total 7 articles about (2R,5S)-2,5-dibutyl-1-[(4-methylphenyl)sulfonyl]pyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
for 3h;
Ambient temperature;
DOI:10.1021/jo00290a010
- Guidance literature:
-
Multi-step reaction with 6 steps
1: LiCl, p-benzoquinone / Pd(OAc)2 / pentane; acetic acid / 28 h / Ambient temperature
2: Pd(PPh3)4 / acetonitrile / 3 h / Ambient temperature
3: 100 percent / aqueous NaOH / methanol / 0.75 h / Heating
4: 100 percent / H2 / PtO2 / methanol / 3 h / 3800 Torr / Ambient temperature
5: 95 percent / triethylamine / tetrahydrofuran / 1) 0 deg C, 1.5 h, 2) RT, 1 h
6: 98 percent / K2CO3 / methanol / 3 h / Ambient temperature
With
sodium hydroxide; hydrogen; potassium carbonate; triethylamine; p-benzoquinone; lithium chloride;
platinum(IV) oxide; palladium diacetate; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; acetic acid; acetonitrile; pentane;
DOI:10.1021/jo00290a010
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Pd(PPh3)4 / acetonitrile / 3 h / Ambient temperature
2: 100 percent / aqueous NaOH / methanol / 0.75 h / Heating
3: 100 percent / H2 / PtO2 / methanol / 3 h / 3800 Torr / Ambient temperature
4: 95 percent / triethylamine / tetrahydrofuran / 1) 0 deg C, 1.5 h, 2) RT, 1 h
5: 98 percent / K2CO3 / methanol / 3 h / Ambient temperature
With
sodium hydroxide; hydrogen; potassium carbonate; triethylamine;
platinum(IV) oxide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jo00290a010
