Antibiotic 593A

Base Information

Chemical Name:Antibiotic 593A
CAS No.:41871-93-6
Molecular Formula:
Molecular Weight:0
Hs Code.:
UNII:67QQU5F3BL
Nikkaji Number:J19.322D
Wikidata:Q27896715
ChEMBL ID:CHEMBL2008217
Mol file:41871-93-6.mol

Synonyms:3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione;3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione, (3S-(3alpha(2S*,5R*),6alpha(2S*,5R*)))-isomer;3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione, dihydrochloride, (3S-(3alpha(2S*,5R*),6alpha(2S*,5R*)))-isomer;593A;NSC-135758;piperazinedione

Suppliers and Price of Antibiotic 593A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of Antibiotic 593A

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:348.1119813
Heavy Atom Count:22
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(NCC1Cl)C2C(=O)NC(C(=O)N2)C3CCC(CN3)Cl
Isomeric SMILES:C1C[C@@H](NC[C@H]1Cl)[C@H]2C(=O)N[C@H](C(=O)N2)[C@H]3CC[C@@H](CN3)Cl

Technology Process of Antibiotic 593A

There total 5 articles about Antibiotic 593A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74015-63-7,74015-64-8
{(E)-(R)-1-[(2S,5S)-5-((E)-(R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pent-2-enyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pent-2-enyl}-carbamic acid benzyl ester

: 41871-93-6,64474-15-3
dl-593A

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / hydrogen / PtO₂ / methanol / Ambient temperature

2: 91 percent / camphorsulfonic acid, quinoline / toluene; 1,2-dichloro-ethane / Heating

3: Cl₂ / CH₂Cl₂ / 0 °C

4: 1.) boron trichloride, 2.) NaBH₃CN, AcOH / 1) CH₂Cl₂, room temperature; 2) methanol

With quinoline; camphor-10-sulfonic acid; hydrogen; chlorine; boron trichloride; sodium cyanoborohydride; acetic acid; platinum(IV) oxide; In methanol; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ja00526a076

Reference yield:

: 74015-66-0
C₃₀H₃₂N₄O₆

: 41871-93-6,64474-15-3
dl-593A

Guidance literature:: Multi-step reaction with 2 steps

1: Cl₂ / CH₂Cl₂ / 0 °C

2: 1.) boron trichloride, 2.) NaBH₃CN, AcOH / 1) CH₂Cl₂, room temperature; 2) methanol

With chlorine; boron trichloride; sodium cyanoborohydride; acetic acid; In dichloromethane;
DOI:10.1021/ja00526a076

Reference yield:

: 74015-65-9
{(R)-1-[(2S,5S)-5-((R)-1-Benzyloxycarbonylamino-5,5-dimethoxy-pentyl)-3,6-dioxo-piperazin-2-yl]-5,5-dimethoxy-pentyl}-carbamic acid benzyl ester

: 41871-93-6,64474-15-3
dl-593A

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / camphorsulfonic acid, quinoline / toluene; 1,2-dichloro-ethane / Heating

2: Cl₂ / CH₂Cl₂ / 0 °C

3: 1.) boron trichloride, 2.) NaBH₃CN, AcOH / 1) CH₂Cl₂, room temperature; 2) methanol

With quinoline; camphor-10-sulfonic acid; chlorine; boron trichloride; sodium cyanoborohydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ja00526a076