Phosphonic acid, [2-[[(1E)-1-[(cyclohexylamino)carbonyl]-2-hydroxy-2-phenylethenyl](phen ylmethyl)amino]-2-oxoethyl]-, diethyl ester

Base Information

• Chemical Name: Phosphonic acid, [2-[[(1E)-1-[(cyclohexylamino)carbonyl]-2-hydroxy-2-phenylethenyl](phen ylmethyl)amino]-2-oxoethyl]-, diethyl ester
• CAS No.: 652965-00-9
• Molecular Formula: C28H37N2O6P
• Molecular Weight: 528.585
• Mol file: 652965-00-9.mol

Synonyms:

Chemical Property of Phosphonic acid, [2-[[(1E)-1-[(cyclohexylamino)carbonyl]-2-hydroxy-2-phenylethenyl](phen ylmethyl)amino]-2-oxoethyl]-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, [2-[[(1E)-1-[(cyclohexylamino)carbonyl]-2-hydroxy-2-phenylethenyl](phen ylmethyl)amino]-2-oxoethyl]-, diethyl ester

There total 1 articles about Phosphonic acid, [2-[[(1E)-1-[(cyclohexylamino)carbonyl]-2-hydroxy-2-phenylethenyl](phen ylmethyl)amino]-2-oxoethyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

diethylphosphonoacetic acid (3095-95-2) + Cyclohexyl isocyanide (931-53-3) + phenylglyoxal hydrate (1074-12-0) + benzylamine (100-46-9) → {[benzyl-(1-cyclohexylcarbamoyl-2-hydroxy-2-phenyl-vinyl)-carbamoyl]-methyl}-phosphonic acid diethyl ester (652965-00-9)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1021/ol035787n

Reference yield:

{[benzyl-(1-cyclohexylcarbamoyl-2-hydroxy-2-phenyl-vinyl)-carbamoyl]-methyl}-phosphonic acid diethyl ester (652965-00-9) → 1-benzyl-5-oxo-3-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid cyclohexyl amide

Guidance literature:

With triethylamine; lithium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 12.5h;

DOI:10.1021/ol035787n

Reference yield:

{[benzyl-(1-cyclohexylcarbamoyl-2-hydroxy-2-phenyl-vinyl)-carbamoyl]-methyl}-phosphonic acid diethyl ester (652965-00-9) → 1-[2,3-methoxy]-phenylethyl-5-oxo-3-phenyl-2,5-dihydro-1H-pyrrol-2-carboxylic acid cyclohexyl amide

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 20 °C

2: 459 mg / LiCl; Et₃N / tetrahydrofuran / 12.5 h / 0 - 20 °C

With triethylamine; lithium chloride; In tetrahydrofuran; methanol; 1: Ugi reaction / 2: Horner-Wadsworth-Emmons reaction;

DOI:10.1021/ol035787n

upstream raw materials:

diethylphosphonoacetic acid

Cyclohexyl isocyanide

phenylglyoxal hydrate

benzylamine