(3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid

Base Information

Chemical Name:(3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid
CAS No.:652971-20-5
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:
Mol file:652971-20-5.mol

Synonyms:(3S,4R)-1-(tert-Butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid;

Suppliers and Price of (3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(3S,4R)-1-(TERT-BUTOXYCARBONYL)-4-PHENYLPIPERIDINE-3-CARBOXYLIC ACID 95.00%
1G
$ 525.00

American Custom Chemicals Corporation
(3S,4R)-1-(TERT-BUTOXYCARBONYL)-4-PHENYLPIPERIDINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 501.49

Total 11 raw suppliers

Chemical Property of (3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid

Chemical Property:

Boiling Point:454.9±45.0 °C(Predicted)
PKA:4.34±0.40(Predicted)
PSA：66.84000
Density:1.169±0.06 g/cm3(Predicted)
LogP:3.04970

Purity/Quality:

97% ^*data from raw suppliers

(3S,4R)-1-(TERT-BUTOXYCARBONYL)-4-PHENYLPIPERIDINE-3-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid

There total 2 articles about (3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-tert-butyl 3-methyl (3R,4R)-4-phenylpiperidine-1,3-dicarboxylate

: 652971-20-5
(3S,4R)-trans-N-(tert-butoxycarbonyl)-4-phenyl-3-carboxypiperidine

Guidance literature:: 1-tert-butyl 3-methyl (3R,4R)-4-phenylpiperidine-1,3-dicarboxylate; With methanol; sodium; at 65 ℃;

With sodium hydroxide; In methanol; at 65 ℃;
DOI:10.1016/j.bmcl.2003.09.026

Reference yield:

: 197900-84-8
(3R,4R)-cis-N-(tert-butoxycarbonyl)-4-phenyl-3-carboxypiperidine

: 652971-20-5
(3S,4R)-trans-N-(tert-butoxycarbonyl)-4-phenyl-3-carboxypiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether; methanol

2.1: Na; methanol / 65 °C

2.2: aq. NaOH / methanol / 65 °C

With methanol; sodium; In methanol; diethyl ether;
DOI:10.1016/j.bmcl.2003.09.026

Reference yield:

: 652971-20-5
(3S,4R)-trans-N-(tert-butoxycarbonyl)-4-phenyl-3-carboxypiperidine

: 652971-23-8
4-(3-amino-butyl)-6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-2H-pyridazin-3-one

: (3S,4R)-3-{(R)-3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propylcarbamoyl}-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2003.09.026