Butanoic acid, 2-[4-[3-[[6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-1-benzopyran-7-yl] oxy]propoxy]phenoxy]-2-methyl-, methyl ester, (2S)-

Base Information

Chemical Name:Butanoic acid, 2-[4-[3-[[6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-1-benzopyran-7-yl] oxy]propoxy]phenoxy]-2-methyl-, methyl ester, (2S)-
CAS No.:653563-82-7
Molecular Formula:C27H30ClF3O6
Molecular Weight:542.98
Hs Code.:

Synonyms:

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Chemical Property of Butanoic acid, 2-[4-[3-[[6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-1-benzopyran-7-yl] oxy]propoxy]phenoxy]-2-methyl-, methyl ester, (2S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Butanoic acid, 2-[4-[3-[[6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-1-benzopyran-7-yl] oxy]propoxy]phenoxy]-2-methyl-, methyl ester, (2S)-

There total 7 articles about Butanoic acid, 2-[4-[3-[[6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-1-benzopyran-7-yl] oxy]propoxy]phenoxy]-2-methyl-, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3196-15-4,69043-96-5
Methyl 2-bromobutyrate

: 653563-82-7
(2S)-methyl 2-(4-(3-((6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-chromen-7-yl)oxy)propoxy)phenoxy)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / acetonitrile / 20 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 4 h / -78 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2068.65 Torr

4.1: Resolution of racemate

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

With hydrogen; caesium carbonate; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 653563-74-7
methyl 2-(4-(benzyloxy)phenoxy)butanoate

: 653563-82-7
(2S)-methyl 2-(4-(3-((6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-chromen-7-yl)oxy)propoxy)phenoxy)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 4 h / -78 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2068.65 Torr

3.1: Resolution of racemate

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

With hydrogen; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 653563-75-8
methyl (4-(benzyloxy)phenoxy)-2-methylbutanoate

: 653563-82-7
(2S)-methyl 2-(4-(3-((6-chloro-2,2-dimethyl-4-(trifluoromethyl)-2H-chromen-7-yl)oxy)propoxy)phenoxy)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2068.65 Torr

2: Resolution of racemate

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol;