2-Benzofurancarboxylicacid,2-ethyl-2,3-dihydro-6-hydroxy-,methylester(9CI)

Base Information

Chemical Name:2-Benzofurancarboxylicacid,2-ethyl-2,3-dihydro-6-hydroxy-,methylester(9CI)
CAS No.:653578-60-0
Molecular Formula:C12H14O4
Molecular Weight:222.23700
Hs Code.:
Mol file:653578-60-0.mol

Synonyms:2-Hexenoic acid,2-ethyl-4-(phenylthio)-,methyl ester,(E);methyl 2-ethyl-4-phenylthiohex-2-enoate;2-Hexenoic acid,2-ethyl-4-(phenylthio)-,methyl ester,(Z);

Suppliers and Price of 2-Benzofurancarboxylicacid,2-ethyl-2,3-dihydro-6-hydroxy-,methylester(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2-Benzofurancarboxylicacid,2-ethyl-2,3-dihydro-6-hydroxy-,methylester(9CI)

Chemical Property:

PSA：55.76000
LogP:1.64890

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Benzofurancarboxylicacid,2-ethyl-2,3-dihydro-6-hydroxy-,methylester(9CI)

There total 4 articles about 2-Benzofurancarboxylicacid,2-ethyl-2,3-dihydro-6-hydroxy-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-ethyl-6-methoxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

: 653578-60-0
methyl 2-ethyl-6-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃;
DOI:10.1021/jm050373g

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 653578-60-0
methyl 2-ethyl-6-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Cs₂CO₃ / dimethylformamide / 50 - 150 °C

2.1: H₂ / Pd/C / ethanol / 72 h / 2327.17 Torr

3.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

3.2: tetrahydrofuran / -78 - 25 °C

4.1: BBr₃ / CH₂Cl₂ / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; boron tribromide; caesium carbonate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050373g

Reference yield:

: 55364-67-5
6-methoxy-2-benzofurancarboxylic acid methyl ester

: 653578-60-0
methyl 2-ethyl-6-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethanol / 72 h / 2327.17 Torr

2.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 - 25 °C

3.1: BBr₃ / CH₂Cl₂ / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; boron tribromide; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm050373g