Technology Process of Cyclopropanecarboxylic acid,
2-(hydroxymethyl)-3-[(phenylmethoxy)methyl]-, methyl ester,
(1R,2S,3R)-
There total 9 articles about Cyclopropanecarboxylic acid,
2-(hydroxymethyl)-3-[(phenylmethoxy)methyl]-, methyl ester,
(1R,2S,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
DOI:10.1021/jm030967o
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 91 percent / AcONa / tetrahydrofuran / 0.5 h / Heating
2: Et3N; p-acetamidobenzenesulfonyl azide / acetonitrile / 2.5 h / 20 °C
3: 3.7 g / aq. LiOH / acetonitrile / 20 °C
4: 65 percent / Rh2(4S-MPPIM)4 / CH2Cl2 / Heating
5: aq. LiOH / tetrahydrofuran / 2 h / 20 °C
6: 0.65 g / diethyl ether / 1 h / 0 °C
7: 88 percent / imidazole / dimethylformamide / 2 h / 20 °C
8: KHMDS / tetrahydrofuran; toluene / 2.67 h / -78 - -10 °C
9: 0.22 g / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
With
1H-imidazole; lithium hydroxide; Rh2(4S-MPPIM)4; 4-acetamidobenzenesulfonyl azide; tetrabutyl ammonium fluoride; sodium acetate; potassium hexamethylsilazane; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm030967o
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 65 percent / Rh2(4S-MPPIM)4 / CH2Cl2 / Heating
2: aq. LiOH / tetrahydrofuran / 2 h / 20 °C
3: 0.65 g / diethyl ether / 1 h / 0 °C
4: 88 percent / imidazole / dimethylformamide / 2 h / 20 °C
5: KHMDS / tetrahydrofuran; toluene / 2.67 h / -78 - -10 °C
6: 0.22 g / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
With
1H-imidazole; lithium hydroxide; Rh2(4S-MPPIM)4; tetrabutyl ammonium fluoride; potassium hexamethylsilazane;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm030967o
