1-CHLORO-3-PHTHALIMIDO-2-PROPANONE

Base Information

• Chemical Name: 1-CHLORO-3-PHTHALIMIDO-2-PROPANONE
• CAS No.: 35750-02-8
• Molecular Formula: C11H8 Cl N O3
• Molecular Weight: 237.642
• Hs Code.: 2925190090
• Mol file: 35750-02-8.mol

Synonyms:1-Chloro-3-phthalimido-2-propanone;NSC 11750

Chemical Property of 1-CHLORO-3-PHTHALIMIDO-2-PROPANONE

Chemical Property:

• Vapor Pressure: 5.61E-06mmHg at 25°C
• Melting Point: 138℃
• Boiling Point: 380°Cat760mmHg
• PKA: -2.56±0.20(Predicted)
• Flash Point: 183.6°C
• PSA: 54.45000
• Density: 1.438g/cm³
• LogP: 1.02840
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

2-(3-Chloro-2-oxopropyl)isoindoline-1,3-dione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLORO-3-PHTHALIMIDO-2-PROPANONE

There total 8 articles about 1-CHLORO-3-PHTHALIMIDO-2-PROPANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione (19667-37-9,34839-11-7,148857-42-5,148857-44-7) → 2-(3-chloro-2-oxopropyl)-1H-isoindole-1,3(2H)-dione (35750-02-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/j.tetasy.2004.01.024

Reference yield:

1-diazo-3-phthalimidopropan-2-one (19791-68-5) → 2-(3-chloro-2-oxopropyl)-1H-isoindole-1,3(2H)-dione (35750-02-8)

Guidance literature:

With hydrogenchloride; water; acetic acid;

DOI:10.1021/jo50002a020

Reference yield:

N-phthaloylglycine chloride (6780-38-7) → 2-(3-chloro-2-oxopropyl)-1H-isoindole-1,3(2H)-dione (35750-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: acetic acid; water; hydrochloric acid

With hydrogenchloride; diethyl ether; water; acetic acid;

DOI:10.1021/jo50002a020

upstream raw materials:

2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione

1-diazo-3-phthalimidopropan-2-one

potassium phtalimide

N-phthaloylglycine chloride

Downstream raw materials:

6-benzyloxy-4-cyano-4-ethoxycarbonyl-1,2,3,4-tetrahydro-1-amino methylene>carbazole

6-benzyloxy-4-cyano-4-ethoxycarbonyl-1,2,3,4-tetrahydro-2-amino methylene>carbazole

5-(5-benzyloxy-3-indolyl)-4-cyano-4-ethoxycarbonyl-1-(N-phthalimidyl)pentan-2-one

6-benzyloxy-4-cyano-4-ethoxycarbonyl-1H-2,3-dihydro-1-(N-phthalimidyl methylene)carbazole

Refernces

• 1、 Mustafin, A. G.,Sakhautdinov, I. M.,Sakhautdinova, G. F.. "Synthesis of New Methanofullerenes with Phthalimide Fragment". . p. 244 - 248. Retrieved 2020/04/17.
• 2、 Pace, Vittorio,Martínez, Fernando,Nova, Clara I.,Fernández, María,Sinisterra, José Vicente,Alcántara, Andrés R.. "Efficient Horner-Wadsworth-Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones". supporting information; body text. p. 3050 - 3053. Retrieved 2009/10/11.