Methanesulfonamide, N-[6-[[(1R)-2-hydroxy-1-methylethyl]amino]-2-[(phenylmethyl)sulfonyl]-4- pyrimidinyl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-

Base Information

Chemical Name:Methanesulfonamide, N-[6-[[(1R)-2-hydroxy-1-methylethyl]amino]-2-[(phenylmethyl)sulfonyl]-4- pyrimidinyl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-
CAS No.:654073-45-7
Molecular Formula:C21H34N4O6S2Si
Molecular Weight:530.742
Hs Code.:

Methanesulfonamide,
N-[6-[[(1R)-2-hydroxy-1-methylethyl]amino]-2-[(phenylmethyl)sulfonyl]-4-
pyrimidinyl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-

Synonyms:

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Chemical Property of Methanesulfonamide, N-[6-[[(1R)-2-hydroxy-1-methylethyl]amino]-2-[(phenylmethyl)sulfonyl]-4- pyrimidinyl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-

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Technology Process of Methanesulfonamide, N-[6-[[(1R)-2-hydroxy-1-methylethyl]amino]-2-[(phenylmethyl)sulfonyl]-4- pyrimidinyl]-N-[[2-(trimethylsilyl)ethoxy]methyl]-

There total 4 articles about Methanesulfonamide, N-[6-[[(1R)-2-hydroxy-1-methylethyl]amino]-2-[(phenylmethyl)sulfonyl]-4- pyrimidinyl]-N-[[2-(trimethylsilyl)ethoxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 654073-44-6
N-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide

: 654073-45-7
N-(2-(benzylsulfonyl)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide

Guidance literature:: N-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6h;

With sodium thiosulfate; In dichloromethane; water;

Reference yield:

: N-[2-(benzylthio)-6-chloropyrimidin-4-yl]-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide

: 654073-45-7
N-(2-(benzylsulfonyl)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 4 h / 80 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 148020-95-5
4,6-dihydroxy-2-(phenylmethylthio)-pyrimidine

: 654073-45-7
N-(2-(benzylsulfonyl)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-aniline; trichlorophosphate / 10 h / Heating / reflux

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.33 h / 0 °C

2.2: 3.08 h / 0 - 20 °C

2.3: 24 h / 0 - 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 4 h / 80 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

With sodium hydride; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; DMF (N,N-dimethyl-formamide); dichloromethane;