(R)-3-(2-hydroxyphenoxy)-1,2-propanediol

Base Information

Chemical Name:(R)-3-(2-hydroxyphenoxy)-1,2-propanediol
CAS No.:654674-16-5
Molecular Formula:C9H12O4
Molecular Weight:184.192
Hs Code.:
DSSTox Substance ID:DTXSID00470481
Wikidata:Q82298580

Synonyms:(R)-3-(2-hydroxyphenoxy)-1,2-propanediol;654674-16-5;SCHEMBL6002020;DTXSID00470481;YFTRBASNPFHPAJ-SSDOTTSWSA-N

Suppliers and Price of (R)-3-(2-hydroxyphenoxy)-1,2-propanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (R)-3-(2-hydroxyphenoxy)-1,2-propanediol

Chemical Property:

PSA：69.92000
LogP:0.12420
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:184.07355886
Heavy Atom Count:13
Complexity:140

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)O)OCC(CO)O
Isomeric SMILES:C1=CC=C(C(=C1)O)OC[C@@H](CO)O

Technology Process of (R)-3-(2-hydroxyphenoxy)-1,2-propanediol

There total 2 articles about (R)-3-(2-hydroxyphenoxy)-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 57090-45-6
(2R)-3-chloro-1,2-propanediol

: 120-80-9,19481-10-8,37349-32-9
benzene-1,2-diol

: 654674-16-5
(R)-3-(2-hydroxyphenoxy)propane-1,2-diol

Guidance literature:: (2R)-3-chloro-1,2-propanediol; benzene-1,2-diol; With sodium hydroxide; In water; at 20 ℃; for 6.5h;

With hydrogenchloride; In water; at 0 ℃; pH=1.0;

Reference yield:

: 19826-87-0
3-(2-hydroxy-phenoxy)-propane-1,2-diol

: 654674-16-5
(R)-3-(2-hydroxyphenoxy)propane-1,2-diol

: 119702-04-4
(S)-3-(2-hydroxyphenoxy)propane-1,2-diol

Guidance literature:: In dichloromethane; at 20 - 40 ℃; optical yield given as %ee; Resolution of racemate; Preferential crystallization;
DOI:10.1016/j.mencom.2009.07.012

Reference yield: 92.0%

: 654674-16-5
(R)-3-(2-hydroxyphenoxy)propane-1,2-diol

: 98-59-9
p-toluenesulfonyl chloride

: (R)-1,2-di(4-tolylsulfonyloxy)-3-[2-(4-tolylsulfonyloxy)phenoxy]propane

Guidance literature:: With N,N,N',N'-tetramethylhexamethylenediamine; triethylamine; In acetonitrile; at 0 - 20 ℃; for 3h; Product distribution / selectivity;