(4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol

Base Information

Chemical Name:(4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol
CAS No.:654680-82-7
Molecular Formula:C11H21NO
Molecular Weight:183.29100
Hs Code.:
DSSTox Substance ID:DTXSID70694334
Mol file:654680-82-7.mol

Synonyms:DTXSID70694334;(4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol;654680-82-7

Suppliers and Price of (4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(1R,3R,4S,6S)-(4-AMINO-4,7,7-TRIMETHYL-BICYCLO-[4.1.0]-HEPT-3-YL)METHANOL 95.00%
5MG
$ 504.45

Total 2 raw suppliers

Chemical Property of (4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol

Chemical Property:

Vapor Pressure:0.00215mmHg at 25°C
Boiling Point:257.5oC at 760 mmHg
Flash Point:109.6oC
PSA：46.25000
Density:0.973g/cm3
LogP:2.07860
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:183.162314293
Heavy Atom Count:13
Complexity:226

Purity/Quality:

97% ^*data from raw suppliers

(1R,3R,4S,6S)-(4-AMINO-4,7,7-TRIMETHYL-BICYCLO-[4.1.0]-HEPT-3-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C2C1CC(C(C2)CO)(C)N)C

Technology Process of (4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol

There total 6 articles about (4-Amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 654680-77-0
methyl (1R,3R,4S,6S)-4-amino-4,7,7-trimethylbicyclo[4.1.0]heptane-3-carboxylate

: 654680-82-7
{(1R,3R,4S,6S)-4-amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl}methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2003.10.001

Reference yield:

: 498-15-7,19079-29-9
(+)-Δ³-carene

: 654680-82-7
{(1R,3R,4S,6S)-4-amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl}methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / diethyl ether / 9 h / 20 °C

2: 82 percent / Et₃N; DMAP / tetrahydrofuran / 2 h / 20 °C

3: 89 percent / NaOMe / 2 h / 20 °C

4: 96 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

5: 85 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With dmap; lithium aluminium tetrahydride; sodium methylate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tetasy.2003.10.001

Reference yield:

: 655236-18-3
(1R,3R,5S,7S)-4,4,7-trimethyl-8-azatricyclo[5.2.0.0^3,5]nonan-9-one

: 654680-82-7
{(1R,3R,4S,6S)-4-amino-4,7,7-trimethylbicyclo[4.1.0]heptan-3-yl}methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Et₃N; DMAP / tetrahydrofuran / 2 h / 20 °C

2: 89 percent / NaOMe / 2 h / 20 °C

3: 96 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

4: 85 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With dmap; lithium aluminium tetrahydride; sodium methylate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2003.10.001