5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione
CAS No.:65475-49-2
Molecular Formula:C29H26N2O5
Molecular Weight:482.536
Hs Code.:
DSSTox Substance ID:DTXSID80556792
Nikkaji Number:J339.376C
Wikidata:Q82438479

Synonyms:65475-49-2;DTXSID80556792;5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:482.18417193
Heavy Atom Count:36
Complexity:806

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(=O)C(O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2CC(=O)[C@H](O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of 5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione

There total 5 articles about 5-Methyl-1-{(2R,5R)-4-oxo-5-[(triphenylmethoxy)methyl]oxolan-2-yl}pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 7791-71-1
5'-O-tritylthymidine

: 65475-49-2
1-(5-O-trityl-β-D-glycero-pentofuran-3-ulosyl)thymine

Guidance literature:: With Dess-Martin periodane; In dichloromethane; 1) 0 deg C, 2) room temp.;
DOI:10.1021/jo00305a003

Reference yield:

: 118466-33-4
3'-hydroperoxythymidine

: 65475-49-2
1-(5-O-trityl-β-D-glycero-pentofuran-3-ulosyl)thymine

Guidance literature:: With acetic anhydride; triethylamine;
DOI:10.1016/0040-4039(88)85124-4

Reference yield:

: 104218-44-2
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine

: 65475-49-2
1-(5-O-trityl-β-D-glycero-pentofuran-3-ulosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KO₂, 18-C-6, 2.) acetic acid / 1.) DMF, 30 min., 0 deg C , 2.) 4 min. 100 deg C

2: Et₃N, acetic anhydride

With 18-crown-6 ether; acetic anhydride; acetic acid; triethylamine;
DOI:10.1016/0040-4039(88)85124-4