Technology Process of 4H-Imidazol-4-one,
3,5-dihydro-5-methyl-3-[(1S)-1-phenylethyl]-5-(phenylmethyl)-, (5S)-
There total 7 articles about 4H-Imidazol-4-one,
3,5-dihydro-5-methyl-3-[(1S)-1-phenylethyl]-5-(phenylmethyl)-, (5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 60 percent / triphenylphosphane, triethylamine, CCl4 / acetonitrile / 1) 5 h, room temperature, 2) 12 h, room temperature
2: 1) butyllithium / 1) THF, hexane, -60 deg C, 2) THF, -60 deg C - room temperature
With
tetrachloromethane; n-butyllithium; triethylamine; triphenylphosphine;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) potassium hydroxide / 1) ethanol, water, 20-24 h, reflux, 2) dimethylformamide, 1 h, 90 deg C
2: 60 percent / triphenylphosphane, triethylamine, CCl4 / acetonitrile / 1) 5 h, room temperature, 2) 12 h, room temperature
3: 1) butyllithium / 1) THF, hexane, -60 deg C, 2) THF, -60 deg C - room temperature
With
tetrachloromethane; potassium hydroxide; n-butyllithium; triethylamine; triphenylphosphine;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) butyllithium / 1) THF, -70 deg C, hexane, 10 min, 2) THF, room temperature, 48 h
2: 50percent NaOH, benzyltriethylammoniumchloride / CH2Cl2 / 2 h / Ambient temperature
With
sodium hydroxide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride;
In
dichloromethane;
