1H-Isoindole-1,3(2H)-dione, 2-(5-bromo-3-methyl-2-pyridinyl)-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-(5-bromo-3-methyl-2-pyridinyl)-
CAS No.:655789-35-8
Molecular Formula:C14H9BrN2O2
Molecular Weight:317.142
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-(5-bromo-3-methyl-2-pyridinyl)-

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Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-(5-bromo-3-methyl-2-pyridinyl)-

There total 1 articles about 1H-Isoindole-1,3(2H)-dione, 2-(5-bromo-3-methyl-2-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 85-44-9
phthalic anhydride

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 655789-35-8
2-(3-methyl-5-bromopyridin-2-yl)-isoindole-1,3-dione

Guidance literature:: In dichloromethane; at 190 ℃; for 5h;
DOI:10.1039/c5ra07207g

Reference yield:

: 655789-35-8
2-(3-methyl-5-bromopyridin-2-yl)-isoindole-1,3-dione

: (-)-L-proline-[5-(4'-tert-butylphenyl)-3-vinylpyridin-2-yl]amide

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux; Irradiation

2: acetone / 4 h / Reflux

3: formaldehyd; potassium carbonate / dichloromethane; water / 3 h / 0 - 20 °C

4: hydrazine hydrate / ethanol / 20 °C

5: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 2,6-di-tert-butyl-4-methyl-phenol / water; ethanol; benzene / 4 h / Inert atmosphere; Reflux

6: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere; Reflux

7: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formaldehyd; 2,2'-azobis(isobutyronitrile); 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate; potassium carbonate; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium chloride; In tetrachloromethane; ethanol; dichloromethane; water; acetone; benzene; 3: |Wittig Olefination / 5: |Suzuki Coupling;
DOI:10.1039/c5ra07207g

Reference yield:

: 655789-35-8
2-(3-methyl-5-bromopyridin-2-yl)-isoindole-1,3-dione

: (+)-D-proline-[5-(40-tert-butylphenyl)-3-vinylpyridin-2-yl]amide

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux; Irradiation

2: acetone / 4 h / Reflux

3: formaldehyd; potassium carbonate / dichloromethane; water / 3 h / 0 - 20 °C

4: hydrazine hydrate / ethanol / 20 °C

5: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 2,6-di-tert-butyl-4-methyl-phenol / water; ethanol; benzene / 4 h / Inert atmosphere; Reflux

6: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

7: trifluoroacetic acid / dichloromethane

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formaldehyd; 2,2'-azobis(isobutyronitrile); 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate; potassium carbonate; hydrazine hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium chloride; In tetrachloromethane; ethanol; dichloromethane; water; acetone; benzene; 3: |Wittig Olefination / 5: |Suzuki Coupling;
DOI:10.1039/c5ra07207g