Technology Process of 1-Piperazinecarboxylic acid,
4-[[4-[[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen
yl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester
There total 4 articles about 1-Piperazinecarboxylic acid,
4-[[4-[[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen
yl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
DOI:10.1016/j.bmc.2005.06.039
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / potassium carbonate / dimethylformamide / 4 h / 20 °C
2: 97 percent / H2 / Pd/C / ethyl acetate / 2 h
3: 73 percent / 2-(1-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium*PF6; N,N-diisopropylethylamine / acetonitrile
With
hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2005.06.039
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / H2 / Pd/C / ethyl acetate / 2 h
2: 73 percent / 2-(1-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium*PF6; N,N-diisopropylethylamine / acetonitrile
With
hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2005.06.039
