(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine

Base Information

Chemical Name:(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
CAS No.:656241-17-7
Molecular Formula:C26H42N2O5
Molecular Weight:462.63
Hs Code.:
Mol file:656241-17-7.mol

Synonyms:

Suppliers and Price of (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
5mg
$ 115.00

American Custom Chemicals Corporation
(2S,5R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-((2S)-2-((4-METHOXY-3-(3-METHOXYPROPOXY)PHENYL)METHYL)-3-METHYLBUTYL)-5-(1-METHYLETHYL)PYRAZINE 95.00%
1G
$ 1686.30

American Custom Chemicals Corporation
(2S,5R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-((2S)-2-((4-METHOXY-3-(3-METHOXYPROPOXY)PHENYL)METHYL)-3-METHYLBUTYL)-5-(1-METHYLETHYL)PYRAZINE 95.00%
25MG
$ 963.50

American Custom Chemicals Corporation
(2S,5R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-((2S)-2-((4-METHOXY-3-(3-METHOXYPROPOXY)PHENYL)METHYL)-3-METHYLBUTYL)-5-(1-METHYLETHYL)PYRAZINE 95.00%
5MG
$ 786.50

Total 2 raw suppliers

Chemical Property of (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine

Chemical Property:

PSA：70.87000
LogP:3.68310
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate in the preparation of Aliskiren.

Technology Process of (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine

There total 12 articles about (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 172900-69-5
(R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene

: 656241-17-7
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In hexane; at -75 ℃; for 0.5h;

(R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene; In tetrahydrofuran; at -75 - -20 ℃; for 20h;
DOI:10.1002/hlca.200390235

Reference yield: 80.0%

: 900811-38-3
(R)--4-(2-(iodomethyl)--3--methylbutyl)--1--methoxy-2--(3--methoxypropoxy)benzene

: 656241-17-7
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexanes; for 0.75h; Cooling with acetone-dry ice;

(R)--4-(2-(iodomethyl)--3--methylbutyl)--1--methoxy-2--(3--methoxypropoxy)benzene; In tetrahydrofuran; hexanes; at -78 ℃; for 16h; Cooling with acetone-dry ice;

Reference yield: 80.0%

: 900811-38-3
(R)--4-(2-(iodomethyl)--3--methylbutyl)--1--methoxy-2--(3--methoxypropoxy)benzene

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 656241-17-7
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine

Guidance literature:: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine; With n-butyllithium; In tetrahydrofuran; hexane; for 0.75h; Cooling with acetone-dry ice;

(R)--4-(2-(iodomethyl)--3--methylbutyl)--1--methoxy-2--(3--methoxypropoxy)benzene; In tetrahydrofuran; hexane; at -78 ℃; for 16.1667h; Cooling with acetone-dry ice;