5,7,3',4'-Taxifolin tetramethyl ether

Base Information

• Chemical Name: 5,7,3',4'-Taxifolin tetramethyl ether
• CAS No.: 6563-36-6
• Molecular Formula: C₁₉H₂₀O₇
• Molecular Weight: 360.364
• Mol file: 6563-36-6.mol

Synonyms:(+)-3',4',5,7-tetra-O-methyldihydroquercetin;Tetra-O-methyl-(+)-dihydroquercetin;(+)-3-hydroxy-5,7,3',4'-tetramethoxyflavanone;taxifolin 5,7,3',4'-tetramethyl ether;3',4',5,7-tetramethyldihydroquercetin;5,7,3',4'-taxifolin tetramethyl ether;

Chemical Property of 5,7,3',4'-Taxifolin tetramethyl ether

Chemical Property:

• PSA: 83.45000
• LogP: 2.39830

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7,3',4'-Taxifolin tetramethyl ether

There total 12 articles about 5,7,3',4'-Taxifolin tetramethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

dimethyl sulfate (77-78-1) + taxifolin (480-18-2,17654-26-1,5117-01-1) → (+)-3',4',5,7-tetra-O-methyl-2,3-trans-dihydroquercetin (6563-36-6,15507-40-1,35492-17-2,88453-12-7,115728-46-6)

Guidance literature:

With potassium carbonate; at 20 ℃; Inert atmosphere;

DOI:10.3390/molecules26216421

Reference yield: 48.0%

(2R,3S)-(+)-catechin 3',4',5,7-tetramethyl ether (51079-25-5) → 3’,4’,5,7-tetra-O-methyl-4β-hydroxycatechin (35499-74-2) + (+)-(2R,3S,4R)-3,4-dihydroxy-5,7,3',4'-tetramethoxyflavan (87303-89-7) + 3,4-dimethoxy-benzaldehyde (120-14-9) + (+)-3',4',5,7-tetra-O-methyl-2,3-trans-dihydroquercetin (6563-36-6,15507-40-1,35492-17-2,88453-12-7,115728-46-6)

Guidance literature:

With dipotassium peroxodisulfate; copper(II) sulfate; In water; acetonitrile; for 0.916667h; Heating;

DOI:10.1016/S0040-4020(01)87876-5

Reference yield: 46.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + taxifolin (480-18-2,17654-26-1,5117-01-1) → (+)-3',4',5,7-tetra-O-methyl-2,3-trans-dihydroquercetin (6563-36-6,15507-40-1,35492-17-2,88453-12-7,115728-46-6)

Guidance literature:

In methanol; diethyl ether; at 0 ℃; for 8h;

DOI:10.1248/cpb.53.1565

upstream raw materials:

diazomethane

taxifolin

(2R,3S)-(+)-catechin 3',4',5,7-tetramethyl ether

dimethyl sulfate

Downstream raw materials:

(2R,3R)-3-O-acetyl-5,7,3',4'-tetra-O-methyltaxifolin

2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one

(2S)-5,7,3',4'-tetramethoxyflavanone

3’,4’,5,7-tetra-O-methyl-4β-hydroxycatechin