1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl-

Base Information

Chemical Name:1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl-
CAS No.:112633-63-3
Molecular Formula:C16H11 N3 O2
Molecular Weight:277.2774
Hs Code.:
DSSTox Substance ID:DTXSID70150127
Wikidata:Q83016071

Synonyms:BRN 4503349;112633-63-3;1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl-;Pyrrolo(1,2-a)pyrazolo(4,3-e)pyridine-4-carboxylic acid, 1-phenyl-;DTXSID70150127;LS-128978

Suppliers and Price of 1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl-

Chemical Property:

Vapor Pressure:0.000132mmHg at 25°C
Boiling Point:320.5°Cat760mmHg
Flash Point:147.6°C
Density:1.4g/cm³
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:277.085126602
Heavy Atom Count:21
Complexity:410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)N2C3=C(C=N2)C(=CC4=CC=CN43)C(=O)O

Technology Process of 1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl-

There total 7 articles about 1H-Pyrazolo(3,4-e)indolizine-4-carboxylic acid, 1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 112633-60-0
4-Cyano-1-phenyl-1H-pyrazolo<3,4-e>indolizine

: 112633-63-3
1-Phenyl-1H-pyrazolo<3,4-e>indolizin-4-carboxylic Acid

Guidance literature:: With potassium hydroxide; In ethylene glycol; at 140 ℃; overnight;
DOI:10.1002/jhet.5570240451

Reference yield:

: 94692-05-4
ethyl 1-phenyl-5-(pyrrol-1-yl)-1H-pyrazole-4-carboxylate

: 112633-63-3
1-Phenyl-1H-pyrazolo<3,4-e>indolizin-4-carboxylic Acid

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 88 percent / POCl₃ / CHCl₃ / 1.5 h / Ambient temperature

3: 89 percent / acetonitrile / 3 h / Ambient temperature

4: 39 percent / POCl₃ / 50 - 60 °C / overnight

5: 44 percent / KOH / ethane-1,2-diol / 140 °C / overnight

With potassium hydroxide; lithium aluminium tetrahydride; trichlorophosphate; In tetrahydrofuran; chloroform; ethylene glycol; acetonitrile;
DOI:10.1002/jhet.5570240451

Reference yield:

: 112633-58-6
4-Hydroxymethyl-1-phenyl-5-(1-pyrryl)pyrazole

: 112633-63-3
1-Phenyl-1H-pyrazolo<3,4-e>indolizin-4-carboxylic Acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / POCl₃ / CHCl₃ / 1.5 h / Ambient temperature

2: 89 percent / acetonitrile / 3 h / Ambient temperature

3: 39 percent / POCl₃ / 50 - 60 °C / overnight

4: 44 percent / KOH / ethane-1,2-diol / 140 °C / overnight

With potassium hydroxide; trichlorophosphate; In chloroform; ethylene glycol; acetonitrile;
DOI:10.1002/jhet.5570240451