Technology Process of Bis(5-bromo-2-pyridinyl)methanone
There total 2 articles about Bis(5-bromo-2-pyridinyl)methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,5-dibromopyridine;
With
n-butyllithium;
In
hexane; toluene;
at -80 ℃;
for 2h;
Diethyl carbonate;
In
hexane; toluene;
at -80 - 20 ℃;
DOI:10.1021/jo035157z
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 14h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydroxylamine hydrochloride; pyridine / ethanol / 1.5 h / Heating
2: Zn; acetic acid / H2O / 0.5 h / 20 °C
3: 0.83 g / diisopropylethylamine / acetonitrile / 48 h / 80 °C
4: Pd(PPh3)4; Na2CO3; ethylene glycol / H2O; toluene / 18 h / Heating
With
pyridine; tetrakis(triphenylphosphine) palladium(0); hydroxylamine hydrochloride; sodium carbonate; ethylene glycol; acetic acid; N-ethyl-N,N-diisopropylamine; zinc;
In
ethanol; water; toluene; acetonitrile;
4: Suzuki-Miyaura reaction;
DOI:10.1021/jo035157z