Tert-butyl 3-amino-4-fluorobenzylcarbamate

Base Information

Chemical Name:Tert-butyl 3-amino-4-fluorobenzylcarbamate
CAS No.:657409-24-0
Molecular Formula:C12H17FN2O2
Molecular Weight:240.278
Hs Code.:
DSSTox Substance ID:DTXSID00701803
Wikidata:Q82633573
Mol file:657409-24-0.mol

Synonyms:TERT-BUTYL 3-AMINO-4-FLUOROBENZYLCARBAMATE;657409-24-0;tert-butyl N-[(3-amino-4-fluorophenyl)methyl]carbamate;DTXSID00701803;ZESPVVPBNKPRRE-UHFFFAOYSA-N;MFCD09263963;AB50273;t-Butyl 3-amino-4-fluorobenzylcarbamate;C90515;EN300-7171562;tert-butyl (3-amino-4-fluorophenyl)methylcarbamate;tert-butyl(3-amino-4-fluorophenyl)methylcarbamate;tert-Butyl [(3-amino-4-fluorophenyl)methyl]carbamate;Z1505710416

Suppliers and Price of Tert-butyl 3-amino-4-fluorobenzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-3-AMINO-4-FLUOROBENZYLCARBAMATE 95.00%
5MG
$ 495.91

Total 7 raw suppliers

Chemical Property of Tert-butyl 3-amino-4-fluorobenzylcarbamate

Chemical Property:

PSA：67.84000
LogP:3.21820
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:240.12740595
Heavy Atom Count:17
Complexity:266

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTYL-3-AMINO-4-FLUOROBENZYLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1=CC(=C(C=C1)F)N

Technology Process of Tert-butyl 3-amino-4-fluorobenzylcarbamate

There total 5 articles about Tert-butyl 3-amino-4-fluorobenzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 903556-46-7
C₂₀H₂₃FN₂O₄

: 657409-24-0
tert-butyl (3-amino-4-fluorobenzyl)carbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16.5h;

Reference yield: 51.0%

: 657409-24-0
tert-butyl (3-amino-4-fluorobenzyl)carbamate

Guidance literature:: With methanol; sodium tetrahydroborate; nickel dichloride; at 0 ℃; for 72h;

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 657409-24-0
tert-butyl (3-amino-4-fluorobenzyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: NH₂OH*HCl; pyridine / methanol

2: NaBH₄ / methanol / -30 °C

3: NiCl₂*6H₂O

With pyridine; sodium tetrahydroborate; hydroxylamine hydrochloride; nickel dichloride; In methanol;
DOI:10.1016/j.bmcl.2003.09.024