3-(CHLOROMETHYL)-5-(3-METHYLPHENYL)-1,2,4-OXADIAZOLE

Base Information

• Chemical Name: 3-(CHLOROMETHYL)-5-(3-METHYLPHENYL)-1,2,4-OXADIAZOLE
• CAS No.: 657423-51-3
• Molecular Formula: C10H9ClN2O
• Molecular Weight: 208.64400
• Mol file: 657423-51-3.mol

Synonyms:3-chloromethyl-5-(3-methyl-phenyl)-[1,2,4]oxadiazole;

Chemical Property of 3-(CHLOROMETHYL)-5-(3-METHYLPHENYL)-1,2,4-OXADIAZOLE

Chemical Property:

• PSA: 38.92000
• LogP: 2.78380

Purity/Quality:

99% ^*data from raw suppliers

3-(chloromethyl)-5-(3-methylphenyl)-1,2,4-oxadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(CHLOROMETHYL)-5-(3-METHYLPHENYL)-1,2,4-OXADIAZOLE

There total 6 articles about 3-(CHLOROMETHYL)-5-(3-METHYLPHENYL)-1,2,4-OXADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-2-chloro-N'-hydroxyethanimidamide (3272-96-6) + 3-Methylbenzoyl chloride (1711-06-4) → 3-Chloromethyl-5-m-tolyl-[1,2,4]oxadiazole (657423-51-3)

Guidance literature:

(Z)-2-chloro-N'-hydroxyethanimidamide; 3-Methylbenzoyl chloride; In dichloromethane; at 20 ℃; for 0.5h;

With triethylamine; In dichloromethane; for 1h;

In N,N-dimethyl-formamide; at 135 ℃; for 4h;

Reference yield:

C10H11ClN2O2 (660416-41-1) → 3-Chloromethyl-5-m-tolyl-[1,2,4]oxadiazole (657423-51-3)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1016/j.bmcl.2004.11.044 DOI:10.1016/j.bmcl.2004.09.077

Reference yield:

C10H11ClN2O2 (660416-41-1) → 3-Chloromethyl-5-m-tolyl-[1,2,4]oxadiazole (657423-51-3)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 135 ℃; for 4h;

upstream raw materials:

C₁₀H₁₁ClN₂O₂

(Z)-2-chloro-N'-hydroxyethanimidamide

3-Methylbenzoyl chloride

2-chloro-N-hydroxyethanimidamide