5-chloro-2-fluorobenzohydrazide

Base Information

• Chemical Name: 5-chloro-2-fluorobenzohydrazide
• CAS No.: 657424-44-7
• Molecular Formula: C7H6ClFN2O
• Molecular Weight: 188.58700
• Hs Code.: 2928009090
• Mol file: 657424-44-7.mol

Synonyms:

Chemical Property of 5-chloro-2-fluorobenzohydrazide

Chemical Property:

• PSA: 55.12000
• LogP: 2.17380

Purity/Quality:

99%min. ^*data from raw suppliers

5-Chloro-2-fluorobenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-fluorobenzohydrazide

There total 2 articles about 5-chloro-2-fluorobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

methyl 5-chloro-2-fluorobenzoatone (57381-36-9) → 5-chloro-2-fluoro-benzoic acid hydrazide (657424-44-7)

Guidance literature:

With hydrazine; In ethanol; at 20 ℃;

Reference yield:

5-chloro-2-fluoro-benzoyl chloride (394-29-6) → 5-chloro-2-fluoro-benzoic acid hydrazide (657424-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 0 - 20 °C

2: hydrazine / ethanol / 20 °C

With hydrazine; In ethanol; dichloromethane;

Reference yield: 73.0%

5-chloro-2-fluoro-benzoic acid hydrazide (657424-44-7) + 2-chloro-1,1,1-trimethoxyethane (74974-54-2) → 2-(5-chloro-2-fluoro-phenyl)-5-chloromethyl-[1,3,4]oxadiazole (657424-48-1)

Guidance literature:

at 120 ℃; for 1h;

upstream raw materials:

methyl 5-chloro-2-fluorobenzoatone

5-chloro-2-fluoro-benzoyl chloride

Downstream raw materials:

2-(5-chloro-2-fluoro-phenyl)-5-chloromethyl-[1,3,4]oxadiazole

2-(1-bromo-ethyl)-5-(5-chloro-2-fluoro-phenyl)-[1,3,4]oxadiazole

Refernces

• 1、 -. "NEW COMPOUNDS". Page/Page column 61. . Retrieved 2010/11/30.