2H-1-Benzopyran-2-carboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-(2-methoxyphenyl)-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-

Base Information

Chemical Name:2H-1-Benzopyran-2-carboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-(2-methoxyphenyl)-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-
CAS No.:658061-89-3
Molecular Formula:C26H30N4O6
Molecular Weight:494.54
Hs Code.:
Mol file:658061-89-3.mol

2H-1-Benzopyran-2-carboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-(2-methoxyphenyl)-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-

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Chemical Property of 2H-1-Benzopyran-2-carboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-(2-methoxyphenyl)-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-

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Technology Process of 2H-1-Benzopyran-2-carboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-(2-methoxyphenyl)-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy-

There total 5 articles about 2H-1-Benzopyran-2-carboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-(2-methoxyphenyl)-3-methyl-2,4-dioxo-5-pyrimidinyl]-3,4-dihydro-6-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 56305-04-5,53188-07-1
trolox

: 658061-67-7
5,6-diamino-1-(2-methoxy-phenyl)-3-methyl-1H-pyrimidine-2,4-dione

: 658061-89-3
6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid [6-amino-1-(2-methoxy-phenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-amide

Guidance literature:: trolox; With triethylamine; Diphenylphosphinic chloride; In ethyl acetate; for 1h; cooling;

5,6-diamino-1-(2-methoxy-phenyl)-3-methyl-1H-pyrimidine-2,4-dione; With triethylamine; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2003.09.012

Reference yield:

: 59759-02-3
1-(2-Methoxy-phenyl)-3-methyl-urea

: 658061-89-3
6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid [6-amino-1-(2-methoxy-phenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic anhydride / ethyl acetate / 4 h / Heating

2.1: NaOH / H₂O; ethyl acetate / 6 h / 20 °C / pH 10

3.1: sodium nitrite; HCl / H₂O / 2 h

4.1: H₂ / Pd/C / methanol / 1 h

5.1: diphenylphosphoryl chloride; triethylamine / ethyl acetate / 1 h / cooling

5.2: 58 percent / triethylamine / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; acetic anhydride; triethylamine; sodium nitrite; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; water; ethyl acetate;
DOI:10.1016/j.bmc.2003.09.012

Reference yield:

: 1-(2-Cyano-acetyl)-3-(2-methoxy-phenyl)-1-methyl-urea

: 658061-89-3
6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid [6-amino-1-(2-methoxy-phenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOH / H₂O; ethyl acetate / 6 h / 20 °C / pH 10

2.1: sodium nitrite; HCl / H₂O / 2 h

3.1: H₂ / Pd/C / methanol / 1 h

4.1: diphenylphosphoryl chloride; triethylamine / ethyl acetate / 1 h / cooling

4.2: 58 percent / triethylamine / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; sodium nitrite; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; water; ethyl acetate;
DOI:10.1016/j.bmc.2003.09.012