5-CHLORO-4-(CHLOROMETHYL)-3-PHENYLISOXAZOLE

Base Information

• Chemical Name: 5-CHLORO-4-(CHLOROMETHYL)-3-PHENYLISOXAZOLE
• CAS No.: 65926-99-0
• Molecular Formula: C10H6Cl3NO
• Molecular Weight: 262.52000

Synonyms:3-Phenyl-5-chlor-4-dimethylisoxazol;5-chloro-4-dichloromethyl-3-phenyl-isoxazole;

Chemical Property of 5-CHLORO-4-(CHLOROMETHYL)-3-PHENYLISOXAZOLE

Chemical Property:

• PSA: 26.03000
• LogP: 4.47120

Purity/Quality:

5-CHLORO-4-(CHLOROMETHYL)-3-PHENYLISOXAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-4-(CHLOROMETHYL)-3-PHENYLISOXAZOLE

There total 2 articles about 5-CHLORO-4-(CHLOROMETHYL)-3-PHENYLISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-chloro-3-phenylisoxazole-4-carboxaldehyde (100230-72-6) → 5-chloro-4-(dichloromethyl)-3-phenylisoxazole (65926-99-0)

Guidance literature:

With trichlorophosphate; In chloroform; N,N-dimethyl-formamide; for 1h; Heating;

DOI:10.1021/jo00356a039

Reference yield:

3-phenyl-4H-isoxazol-5-one (1076-59-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-chloro-4-(dichloromethyl)-3-phenylisoxazole (65926-99-0)

Guidance literature:

With trichlorophosphate;

Reference yield: 92.0%

5-chloro-4-(dichloromethyl)-3-phenylisoxazole (65926-99-0) + para-chloroacetophenone (99-91-2) → (Z)-1-(4-Chloro-phenyl)-3-(5-methoxy-3-phenyl-isoxazol-4-yl)-propenone (122773-50-6)

Guidance literature:

With sodium hydroxide; In methanol; for 1h;

upstream raw materials:

3-phenyl-4H-isoxazol-5-one

N,N-dimethyl-formamide

5-chloro-3-phenylisoxazole-4-carboxaldehyde

Downstream raw materials:

5-methoxy-3-phenylisoxazole-4-carboxaldehyde

(Z)-1-(4-Chloro-phenyl)-3-(5-methoxy-3-phenyl-isoxazol-4-yl)-propenone

(Z)-1-(4-Bromo-phenyl)-3-(5-methoxy-3-phenyl-isoxazol-4-yl)-propenone

3-phenyl-1-(3-phenyl-5-methoxy-4-isoxazolyl)-1-propen-3-one

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