Technology Process of (4R,5S,6S,7R)-1-benzyl-3-(1-cyclohexa-1,5-dienylmethyl)-4,7-bis(3-furylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one
There total 7 articles about (4R,5S,6S,7R)-1-benzyl-3-(1-cyclohexa-1,5-dienylmethyl)-4,7-bis(3-furylmethyl)-5,6-dihydroxy-1,3-diazepan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
acetonitrile;
for 2h;
Ambient temperature;
DOI:10.1021/jm960083n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) tetrachloroethane, 15 min, 2.) tetrachloroethane, reflux, 15 min
2: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, RT, 2 h
3: 20percent methanolic HCl / acetonitrile / 2 h / Ambient temperature
With
hydrogenchloride; sodium hydride;
In
acetonitrile;
DOI:10.1021/jm960083n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) triphenylphosphine, diethyl azodicarboxylate, 2.) diphenyl phosphorazidate / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 1 h
2: LiAlH4 / tetrahydrofuran; diethyl ether / 0.33 h / Ambient temperature
3: 1.) tetrachloroethane, 15 min, 2.) tetrachloroethane, reflux, 15 min
4: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, RT, 2 h
5: 20percent methanolic HCl / acetonitrile / 2 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; diphenyl phosphoryl azide; sodium hydride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1021/jm960083n
