2-PhenylcyclopentanaMine

Base Information

• Chemical Name: 2-PhenylcyclopentanaMine
• CAS No.: 6604-06-4
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.247
• Mol file: 6604-06-4.mol

Synonyms:Cyclopentylamine,2-phenyl-,trans-;(+/-)-trans-2-Phenylcyclopentanamine;Trans-cypenamine;Cyclopentanamine,2-phenyl-,(1R,2S)-rel-;(+/-)-trans-2-Phenylcyclopentylamine;Cyclopentanamine,2-phenyl-,trans-;

Chemical Property of 2-PhenylcyclopentanaMine

Chemical Property:

• PSA: 26.02000
• LogP: 2.98170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

2-Phenylcyclopentanamine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-PhenylcyclopentanaMine

There total 13 articles about 2-PhenylcyclopentanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

methyl-bis-(2-phenyl-cyclopentyl)-borane → (+/-)-trans-2-phenyl-cyclopentylamine (6604-06-4,15301-54-9,40264-04-8,70450-46-3,70450-50-9)

Guidance literature:

methyl-bis-(2-phenyl-cyclopentyl)-borane; With hydroxylamine-O-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In methanol; diethyl ether; water; at 20 ℃; for 0.5h;

Reference yield: 53.0%

methyl-bis-(2-phenyl-cyclopentyl)borane (477789-52-9) → (+/-)-trans-2-phenyl-cyclopentylamine (6604-06-4,15301-54-9,40264-04-8,70450-46-3,70450-50-9)

Guidance literature:

methyl-bis-(2-phenyl-cyclopentyl)borane; With hydroxylamine-O-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm0105474

Reference yield:

2-phenylcyclopentan-1-one oxime (83849-01-8) → (+/-)-trans-2-phenyl-cyclopentylamine (6604-06-4,15301-54-9,40264-04-8,70450-46-3,70450-50-9) + (+/-)-cis-2-phenyl-cyclopentylamine

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; at 40 ℃; under 3102.99 Torr; Product distribution / selectivity;

upstream raw materials:

cyclopent-1-en-1-ylbenzene

2-phenylcyclopentan-1-one oxime

methyl-bis-(2-phenyl-cyclopentyl)borane

chloro-bis-(2-phenyl-cyclopentyl)borane

Downstream raw materials:

(1S,2R)-2-phenylcyclopentanamine

trans-(1R,2S)-2-phenylcyclopentylamine

Refernces

• 1、 -. "Cyclopentyl sulfonamide derivatives". . . Retrieved 2010/01/31.
• 2、 Brown, Herbert C.,Kim, Kee-Won,Srebnik, Morris,Singaram, Bakthan. "ORGANOBORANES FOR SYNTHESIS. 7. AN IMPROVED GENERAL SYNTHESIS OF PRIMARY AMINES FROM ALKENES via HYDROBORATION-ORGANOBORANE CHEMISTRY". . p. 4071 - 4078. Retrieved 2007/10/02.