6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine

Base Information

Chemical Name:6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine
CAS No.:660432-14-4
Molecular Formula:C18H17N3O2S
Molecular Weight:339.418
Hs Code.:
DSSTox Substance ID:DTXSID10591914
Wikidata:Q82485781

Synonyms:660432-14-4;6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine;SCHEMBL4830336;DTXSID10591914;NYCNFFNAMDEGLK-UHFFFAOYSA-N;1-isopropylsulfonyl-2-amino-6-(phenylethynyl)-benzimidazole

Suppliers and Price of 6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:339.10414797
Heavy Atom Count:24
Complexity:607

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)S(=O)(=O)N1C2=C(C=CC(=C2)C#CC3=CC=CC=C3)N=C1N

Technology Process of 6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine

There total 1 articles about 6-(Phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 536-74-3
phenylacetylene

: 208335-92-6
6-iodo-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

: 660432-14-4
6-(phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-ylamine

Guidance literature:: With copper(l) iodide; bis(triphenylphosphine) palladium (Il) acetate; triethylamine; In dimethyl sulfoxide; at 25 ℃; for 15h;
DOI:10.1021/jm048978k

Reference yield: 83.0%

: 660432-14-4
6-(phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-ylamine

: 660432-17-7
1-[2-amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-2-phenyl-ethane-1,2-dione

Guidance literature:: With potassium permanganate; sodium hydrogencarbonate; magnesium sulfate; In acetone; at 35 ℃; for 1h;
DOI:10.1021/jm048978k

Reference yield:

: 660432-14-4
6-(phenylethynyl)-1-(propane-2-sulfonyl)-1H-benzimidazol-2-ylamine

: 6-[2-(2,6-dichlorophenyl)-5-phenyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / aq. NaHCO₃; MgSO₄; KMnO₄ / acetone / 1 h / 35 °C

2: 20 percent / NH₄OAc; acetic acid / 3 h / 80 °C

With potassium permanganate; ammonium acetate; sodium hydrogencarbonate; magnesium sulfate; acetic acid; In acetone;
DOI:10.1021/jm048978k