1-Piperidinecarboxylic acid, 4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl -1H-imidazol-2-yl]-, phenylmethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl -1H-imidazol-2-yl]-, phenylmethyl ester
CAS No.:660432-91-7
Molecular Formula:C32H34N6O4S
Molecular Weight:598.726
Hs Code.:

1-Piperidinecarboxylic acid,
4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl
-1H-imidazol-2-yl]-, phenylmethyl ester

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl -1H-imidazol-2-yl]-, phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl -1H-imidazol-2-yl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl -1H-imidazol-2-yl]-, phenylmethyl ester

There total 3 articles about 1-Piperidinecarboxylic acid, 4-[4-[2-amino-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-6-yl]-5-phenyl -1H-imidazol-2-yl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 660432-06-4
1-[2-amino-3-(propane-2-sulfonyl)-3H-benzimidazol-5-yl]-2-(tert-butyldimethylsilanyloxy)-2-phenylethanone

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 660432-91-7
6-[2-((N-benzyloxycarbonyl)-4-piperidyl)-5-phenyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

Guidance literature:: With copper diacetate; ammonium acetate; acetic acid; at 100 ℃; for 2h;
DOI:10.1021/jm048978k

Reference yield:

: N-methyl-N-methoxy-2-tert-butyldimethylsilyloxy-2-phenylacetamide

: 660432-91-7
6-[2-((N-benzyloxycarbonyl)-4-piperidyl)-5-phenyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPrMgCl / tetrahydrofuran / 1 h / 0 °C

1.2: 50 percent / tetrahydrofuran / 2.5 h / 0 - 20 °C

2.1: 36 percent / Cu(OAc)2; NH₄OAc; acetic acid / 2 h / 100 °C

With copper diacetate; ammonium acetate; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm048978k

Reference yield:

: 208335-92-6
6-iodo-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

: 660432-91-7
6-[2-((N-benzyloxycarbonyl)-4-piperidyl)-5-phenyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzimidazole-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPrMgCl / tetrahydrofuran / 1 h / 0 °C

1.2: 50 percent / tetrahydrofuran / 2.5 h / 0 - 20 °C

2.1: 36 percent / Cu(OAc)2; NH₄OAc; acetic acid / 2 h / 100 °C

With copper diacetate; ammonium acetate; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm048978k