7-Deoxydaunorubicin aglycone

Base Information

• Chemical Name: 7-Deoxydaunorubicin aglycone
• CAS No.: 59367-18-9
• Molecular Formula: C21H18O7
• Molecular Weight: 0

Synonyms:7-Deoxydaunomycinone;7-Desoxydaunomycinone;8-acetyl-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione;5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-;

Chemical Property of 7-Deoxydaunorubicin aglycone

Chemical Property:

• Boiling Point: 692°Cat760mmHg
• Flash Point: 250.2°C
• Density: 1.508g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Deoxydaunorubicin aglycone

There total 4 articles about 7-Deoxydaunorubicin aglycone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6,9,11-trihydroxy-4-methoxy-9-(2-trimethylsilylethynyl)-7,8,9,10-tetrahydronaphthacene-5,12-dione (104079-52-9) → (+/-)-7-Deoxydaunomycinone (59367-18-9,35994-56-0)

Guidance literature:

With sulfuric acid; mercury(II) oxide; In tetrahydrofuran; at 70 ℃; for 1.5h;

DOI:10.1016/S0040-4039(00)83975-1

Reference yield:

2-<1-(1,1-ethylenedioxy)ethyl>-1,2,3,4,6,11-hexahydro-2-hydroxy-5,7,12-trimethoxynapthacene-6,11-quinone (80027-68-5) → (+/-)-7-Deoxydaunomycinone (59367-18-9,35994-56-0)

Guidance literature:

With hydrogenchloride; boron trichloride; Yield given. Multistep reaction; 1.) dioxane, 30 min, 2.) CH₂Cl₂, 10 min;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (+/-)-7-deoxycarminomycinone (64869-79-0) → (+/-)-7-Deoxydaunomycinone (59367-18-9,35994-56-0)

Guidance literature:

DOI:10.1016/0040-4039(80)80203-6

upstream raw materials:

diazomethane

(+/-)-7-deoxycarminomycinone

6,9,11-trihydroxy-4-methoxy-9-(2-trimethylsilylethynyl)-7,8,9,10-tetrahydronaphthacene-5,12-dione

2-<1-(1,1-ethylenedioxy)ethyl>-1,2,3,4,6,11-hexahydro-2-hydroxy-5,7,12-trimethoxynapthacene-6,11-quinone

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