(S)-3-(Pyridine-3-yl)propyl-1-(3,3-dimethyl-2-oxo-pentanoyl)pyrrolidine-2-carboxylate

Base Information

• Chemical Name: (S)-3-(Pyridine-3-yl)propyl-1-(3,3-dimethyl-2-oxo-pentanoyl)pyrrolidine-2-carboxylate
• CAS No.: 186452-09-5
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453
• Hs Code.: 2933990090
• Mol file: 186452-09-5.mol

Synonyms:GPI 1046;L-Proline,1-(3,3-dimethyl-1,2-dioxopentyl)-,3-(3-pyridinyl)propyl ester;

Chemical Property of (S)-3-(Pyridine-3-yl)propyl-1-(3,3-dimethyl-2-oxo-pentanoyl)pyrrolidine-2-carboxylate

Chemical Property:

• Boiling Point: 501.5 °C at 760 mmHg
• PKA: 5.37±0.10(Predicted)
• Flash Point: 257.1 °C
• PSA: 90.40000
• Density: 1.143 g/cm³
• LogP: 1.62950
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

1-(3,3-Dimethyl-1,2-dioxopentyl)-L-proline3-(3-pyridinyl)propylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: GPI 1046 shows some effect on neuron survival and regeneration in studies.

Technology Process of (S)-3-(Pyridine-3-yl)propyl-1-(3,3-dimethyl-2-oxo-pentanoyl)pyrrolidine-2-carboxylate

There total 3 articles about (S)-3-(Pyridine-3-yl)propyl-1-(3,3-dimethyl-2-oxo-pentanoyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-(3-pyridyl)propan-1-ol (2859-67-8) + (2S)-1-(1,2-dioxo-3 3-dimethylpentyl)-2-pyrrolidinecarboxylic acid (186268-78-0) → 3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate (186452-09-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm201746x

Reference yield:

C14H23NO4 (1233885-04-5) → 3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate (186452-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; lithium hydroxide; In dichloromethane;

DOI:10.1021/jm201746x

Reference yield:

→ 3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate (186452-09-5)

Guidance literature:

upstream raw materials:

3-(3-pyridyl)propan-1-ol

(2S)-1-(1,2-dioxo-3 3-dimethylpentyl)-2-pyrrolidinecarboxylic acid

C₁₄H₂₃NO₄

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