4-Formyl-2-hydroxybenzoic acid

Base Information

Chemical Name:4-Formyl-2-hydroxybenzoic acid
CAS No.:51572-88-4
Molecular Formula:C8H6O4
Molecular Weight:166.1308
Hs Code.:
European Community (EC) Number:818-623-9
DSSTox Substance ID:DTXSID20349660
Nikkaji Number:J1.288.474E
Wikidata:Q27103080
Metabolomics Workbench ID:51282
Mol file:51572-88-4.mol

Synonyms:4-Formyl-2-hydroxybenzoic acid;51572-88-4;4-Formylsalicylic acid;4-carboxy-3-hydroxybenzaldehyde;4-formyl salicylic acid;4-Formyl-2-hydroxybenzoicacid;SCHEMBL1124850;CHEBI:20367;DTXSID20349660;MFCD16999740;MB30837;AS-50183;FT-0759812;EN300-153368;O11231;Q27103080;Z1255375223

Suppliers and Price of 4-Formyl-2-hydroxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-Formyl-2-hydroxybenzoic acid

Chemical Property:

Vapor Pressure:1.07E-05mmHg at 25°C
Boiling Point:356.4°Cat760mmHg
Flash Point:183.5°C
Density:1.482g/cm³
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:166.02660867
Heavy Atom Count:12
Complexity:190

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C=O)O)C(=O)O

Technology Process of 4-Formyl-2-hydroxybenzoic acid

There total 5 articles about 4-Formyl-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: tert-butyl 4-aldehyde-2-hydroxybenzoate

: 51572-88-4
4-formyl-2-hydroxybenzoic acid

Guidance literature:: With trifluoroacetic acid; for 1h; Reflux;

Reference yield:

: 42137-51-9
4-formyl-2-hydroxy-benzoic acid methyl ester

: 51572-88-4
4-formyl-2-hydroxybenzoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 25 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1666-28-0
4-bromosalicylic acid

: 51572-88-4
4-formyl-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h

3.1: trifluoroacetic acid / 1 h / Reflux

With dmap; n-butyllithium; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;