6-Quinolinehexanoic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-

Base Information

Chemical Name:6-Quinolinehexanoic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-
CAS No.:660452-01-7
Molecular Formula:C32H42N2O4
Molecular Weight:518.696
Hs Code.:

Synonyms:

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Chemical Property of 6-Quinolinehexanoic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-

Chemical Property:

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Technology Process of 6-Quinolinehexanoic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)-

There total 14 articles about 6-Quinolinehexanoic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-(4-methylphenyl)-2-(2- methylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 660452-00-6
tert-butyl {[6-(5-cyanopentyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 660452-01-7
6-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]hexanoic acid

Guidance literature:: tert-butyl {[6-(5-cyanopentyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate; With sodium hydroxide; In ethanol; for 6h; Reflux;

With hydrogenchloride; In ethanol; water;
DOI:10.1021/jm101236h

Reference yield:

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 660452-01-7
6-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]hexanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2.1: methanesulfonic acid / toluene / 17 h / Reflux

3.1: palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl / tert-butyl alcohol / 15 h / 70 °C / Inert atmosphere

4.1: trifluoroacetic acid / tetrahydrofuran / 4 h / 20 °C

5.1: ammonia; hydrogen / tetrahydrofuran; methanol / 8 h / 70 °C / 3750.38 Torr

6.1: tetrahydrofuran / 3 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

7.2: 0.5 h / 20 °C

8.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / 80 °C / Inert atmosphere

9.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3.5 h / 20 °C

10.1: sodium hydroxide / ethanol / 6 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; methanesulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; palladium diacetate; sodium hydride; 2,2'-bis(diphenylphosphino)biphenyl; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol; 8.1: Sonogashira coupling;
DOI:10.1021/jm101236h

Reference yield:

: C₂₁H₂₄N₂O

: 660452-01-7
6-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / 80 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3.5 h / 20 °C

5.1: sodium hydroxide / ethanol / 6 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil; 3.1: Sonogashira coupling;
DOI:10.1021/jm101236h