1-Hexanol, 2-methyl-, (R)-

Base Information

• Chemical Name: 1-Hexanol, 2-methyl-, (R)-
• CAS No.: 66050-98-4
• Molecular Formula: C7H16O
• Molecular Weight: 116.203
• Mol file: 66050-98-4.mol

Synonyms:

Chemical Property of 1-Hexanol, 2-methyl-, (R)-

Chemical Property:

• PSA: 20.23000
• LogP: 1.80500

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Hexanol, 2-methyl-, (R)-

There total 45 articles about 1-Hexanol, 2-methyl-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-2-Methylhexyl Tetrahydropyranyl Ether (131906-75-7) → (2S)-2-methyl-1-hexanol (624-22-6,66050-98-4,111768-04-8,66050-99-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In ethanol; for 4h; Ambient temperature;

Reference yield: 93.0%

(S)-4-benzyl-3-((S)-2-methylhexanoyl)oxazolidin-2-one (177607-70-4) → (2S)-2-methyl-1-hexanol (624-22-6,66050-98-4,111768-04-8,66050-99-5)

Guidance literature:

With methanol; lithium borohydride; In diethyl ether; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2011.07.105

Reference yield: 90.0%

(S)-4-isopropyl-3-((S)-2-methylhexanoyl)oxazolidin-2-one → (2S)-2-methyl-1-hexanol (624-22-6,66050-98-4,111768-04-8,66050-99-5) + (4S)-4-isopropyl-1,3-oxazolidin-2-one (17016-83-0)

Guidance literature:

With methanol; lithium borohydride; In diethyl ether; at 20 ℃; for 1.5h; Inert atmosphere; Cooling with ice;

DOI:10.1055/s-0035-1561614

upstream raw materials:

2-methylhexanoic acid

(E)-2-methyl-2-hexenal

(2S,3S)-3-Methyl-heptane-1,2-diol

(S)-2-Methylhexyl Tetrahydropyranyl Ether

Downstream raw materials:

(4S,5R)-4-methyl-2-((R)-2-methylhexylselanyl)-5-phenyl-4,5-dihydrooxazole

(2R)-methylhexyl (S)-α-methoxy-α-trifluoromethylphenylacetate

(S)-1-bromo-2-methylhexane

Refernces

• 1、 Drosos, Nikolaos,Cheng, Gui-Juan,Ozkal, Erhan,Cacherat, Bastien,Thiel, Walter,Morandi, Bill. "Catalytic Reductive Pinacol-Type Rearrangement of Unactivated 1,2-Diols through a Concerted, Stereoinvertive Mechanism". supporting information. p. 13377 - 13381. Retrieved 2017/10/17.
• 2、 Zhang, Tao,Ma, Wei-Li,Li, Tian-Rui,Wu, Jia,Wang, Jun-Run,Du, Zhen-Ting. "A facile asymmetric synthesis of (S)-14-methyl-1-octadecene, the sex pheromone of the peach leafminer moth". . p. 5201 - 5208. Retrieved 2013/06/27.