5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole

Base Information

Chemical Name:5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole
CAS No.:163860-25-1
Molecular Formula:C₁₅H₂₀FN₃
Molecular Weight:261.342
Hs Code.:
DSSTox Substance ID:DTXSID00566116
Nikkaji Number:J656.606E
Wikidata:Q82451576
Mol file:163860-25-1.mol

Synonyms:5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole;163860-25-1;5-fluoro-3-(3-piperazin-1-ylpropyl)-1H-indole;5-Fluoro-3-[3-(piperazin-1-yl)propyl]-1H-indole;SCHEMBL9047205;DTXSID00566116

Suppliers and Price of 5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole 95+%
1g
$ 668.00

Chemenu
5-fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole 95%
1g
$ 632.00

Alichem
5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole
1g
$ 565.76

Total 9 raw suppliers

Chemical Property of 5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole

Chemical Property:

Boiling Point:443.8±45.0 °C(Predicted)
PKA:16.50±0.30(Predicted)
PSA：31.06000
Density:1.161±0.06 g/cm3(Predicted)
LogP:2.41150
Storage Temp.:2-8°C
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:261.16412581
Heavy Atom Count:19
Complexity:281

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)CCCC2=CNC3=C2C=C(C=C3)F

Technology Process of 5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole

There total 5 articles about 5-Fluoro-3-(3-(piperazin-1-yl)propyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 110-85-0
piperazine

: 141071-82-1
5-Fluoro-3-(3-p-toluenesulfonyloxypropyl)indole

: 163860-25-1
5-fluoro-3-(3-piperazin-1-yl-propyl)-1H-indole

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Reflux;
DOI:10.1016/j.bmc.2013.10.036

Reference yield: 74.92%

: 163860-25-1
5-fluoro-3-(3-piperazin-1-yl-propyl)-1H-indole

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 5h;

With sodium hydroxide; In methanol; at 90 ℃; for 3h;

Reference yield:

: 141071-80-9
3-(5-fluoro-1H-indol-3-yl)propan-1-ol

: 163860-25-1
5-fluoro-3-(3-piperazin-1-yl-propyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 25 h / 20 °C

2: potassium carbonate / acetonitrile / 6 h / Reflux

With dmap; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2013.10.036