3'-O-ACETYL-2'-DEOXYADENOSINE

Base Information

• Chemical Name: 3'-O-ACETYL-2'-DEOXYADENOSINE
• CAS No.: 6612-73-3
• Molecular Formula: C12H15N5O4
• Molecular Weight: 293.282
• Hs Code.: 2934999090
• Mol file: 6612-73-3.mol

Synonyms:3'-O-Acetyl-2'-desoxyadenosin;O3'-acetyl-2'-deoxy-adenosine;O3'-Acetyl-2'-desoxy-adenosin;3'-O-Acetyl-2'-deoxyadenosin;2'-Deoxyadenosine 3'-acetate;2'-deoxy-3'-O-acetyladenosine;

Chemical Property of 3'-O-ACETYL-2'-DEOXYADENOSINE

Chemical Property:

• Boiling Point: 567.1oC at 760 mmHg
• Flash Point: 296.8oC
• PSA: 125.38000
• Density: 1.73g/cm3
• LogP: 0.20120
• Storage Temp.: −20°C

Purity/Quality:

97% ^*data from raw suppliers

3?-O-Acetyl-2?-deoxyadenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-O-ACETYL-2'-DEOXYADENOSINE

There total 4 articles about 3'-O-ACETYL-2'-DEOXYADENOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

acetic anhydride (108-24-7) + 2'-deoxy-D-adenosine (958-09-8,7005-15-4) → 5'-O-acetyl-2'-deoxyadenosine (72560-67-9) + 3'-O-acetyl-2'-deoxyadenosine (6612-73-3) + 3',5'-di-O-acetyl-2'-deoxyadenosine (17318-24-0)

Guidance literature:

In pyridine; Ambient temperature;

Reference yield:

3',5'-di-O-acetyl-2'-deoxyadenosine (17318-24-0) → 5'-O-acetyl-2'-deoxyadenosine (72560-67-9) + 3'-O-acetyl-2'-deoxyadenosine (6612-73-3) + 2'-deoxy-D-adenosine (958-09-8,7005-15-4)

Guidance literature:

With n-butyllithium; 2,2,2-trifluoroethanol; In hexane; at 20 ℃; for 3.5h;

DOI:10.1021/jo0600104

Reference yield:

Acetic acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester (141479-77-8) → 3'-O-acetyl-2'-deoxyadenosine (6612-73-3) + 2'-deoxy-D-adenosine (958-09-8,7005-15-4)

Guidance literature:

With ammonium fluoride; In methanol; at 60 ℃;

DOI:10.1016/S0040-4039(00)91889-6

upstream raw materials:

N⁶,O^3'-diacetyl-O^5'-trityl-2'-deoxy-adenosine

Acetic acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester

acetic anhydride

2'-deoxy-D-adenosine

Downstream raw materials:

2'-deoxyadenosine-5'-monophosphoric acid

Acetic acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-(1,3-diphenyl-imidazolidin-2-yl)-tetrahydro-furan-3-yl ester

2',5'-dideoxy-5',5'-(N,N-diphenylethylenediamino)adenosine

D-Ribose