L-Glutamic acid, N-[4-[3-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4,5,6,7,8,10-hexahydro-4- oxo-5,9-methanopyrimido[4,5-b]azocin-9(1H)-yl]propyl]benzoyl]-, diethyl ester

Base Information

Chemical Name:L-Glutamic acid, N-[4-[3-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4,5,6,7,8,10-hexahydro-4- oxo-5,9-methanopyrimido[4,5-b]azocin-9(1H)-yl]propyl]benzoyl]-, diethyl ester
CAS No.:661464-56-8
Molecular Formula:C34H47N5O7
Molecular Weight:637.776
Hs Code.:

L-Glutamic acid,
N-[4-[3-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4,5,6,7,8,10-hexahydro-4-
oxo-5,9-methanopyrimido[4,5-b]azocin-9(1H)-yl]propyl]benzoyl]-, diethyl
ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Glutamic acid, N-[4-[3-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4,5,6,7,8,10-hexahydro-4- oxo-5,9-methanopyrimido[4,5-b]azocin-9(1H)-yl]propyl]benzoyl]-, diethyl ester

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Technology Process of L-Glutamic acid, N-[4-[3-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4,5,6,7,8,10-hexahydro-4- oxo-5,9-methanopyrimido[4,5-b]azocin-9(1H)-yl]propyl]benzoyl]-, diethyl ester

There total 4 articles about L-Glutamic acid, N-[4-[3-[2-[(2,2-dimethyl-1-oxopropyl)amino]-4,5,6,7,8,10-hexahydro-4- oxo-5,9-methanopyrimido[4,5-b]azocin-9(1H)-yl]propyl]benzoyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: N{4-[3-(2-amino-4(3H)-oxo-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-9-yl)propenyl]benzoyl}-L-glutamic acid diethyl ester

: 661464-56-8
(S)-2-(4-{3-[5-(2,2-Dimethyl-propionylamino)-3-oxo-4,6,8-triaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,5-dien-9-yl]-propyl}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 5h; under 2068.59 Torr;
DOI:10.3987/com-03-s3

Reference yield:

: 116387-21-4
4-iodobenzoyl-L-glutamic acid diethyl ester

: 661464-56-8
(S)-2-(4-{3-[5-(2,2-Dimethyl-propionylamino)-3-oxo-4,6,8-triaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,5-dien-9-yl]-propyl}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / triethylamine; PPh₃; CuI / Pd(OAc)2 / dimethylformamide; acetonitrile / 10 h / 60 °C

2: 92 percent / H₂ / Pd-C / methanol / 5 h / 2068.59 Torr

With copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; palladium diacetate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile; 1: Heck coupling;
DOI:10.3987/com-03-s3

Reference yield:

: 2-pivaloylamino-9-allyl-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-4(3H)one

: 661464-56-8
(S)-2-(4-{3-[5-(2,2-Dimethyl-propionylamino)-3-oxo-4,6,8-triaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,5-dien-9-yl]-propyl}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / triethylamine; PPh₃; CuI / Pd(OAc)2 / dimethylformamide; acetonitrile / 10 h / 60 °C

2: 92 percent / H₂ / Pd-C / methanol / 5 h / 2068.59 Torr

With copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; palladium diacetate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile; 1: Heck coupling;
DOI:10.3987/com-03-s3