Chemical Property of SEA-0400
Chemical Property:
- Vapor Pressure:1.46E-09mmHg at 25°C
- Boiling Point:485°Cat760mmHg
- Flash Point:247.1°C
- PSA：53.71000
- Density:1.254g/cm3
- LogP:5.89820
- Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Solubility.:insoluble in H2O; ≥18.57 mg/mL in DMSO; ≥46.4 mg/mL in EtOH with ultrasonic
- Purity/Quality:
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99%, *data from raw suppliers
SEA0400 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively). It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson''s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.
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Uses
SEA 0400 is a novel and selective inhibitor of Na+-Ca2+ exchanger.
