1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

Base Information

Chemical Name:1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid
CAS No.:66158-41-6
Molecular Formula:C13H10FNO3
Molecular Weight:247.226
Hs Code.:
DSSTox Substance ID:DTXSID70588648
Wikidata:Q82481457

Synonyms:66158-41-6;1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid;1-(4-fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid;1-[(4-fluorophenyl)methyl]-2-oxopyridine-3-carboxylic acid;1-[(4-Fluorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid;SCHEMBL2621620;DTXSID70588648;KFUPGHOUJJNVJQ-UHFFFAOYSA-N;AKOS005207897;MCULE-2554553706;DA-30988;EN300-238280;F2143-0012;1-(4-fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid

Suppliers and Price of 1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 92%
1g
$ 611.00

Matrix Scientific
1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 92%
2.500g
$ 1334.00

Matrix Scientific
1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 92%
5g
$ 2015.00

Crysdot
1-(4-Fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid 97%
1g
$ 381.00

Crysdot
1-(4-Fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid 97%
10g
$ 1439.00

Crysdot
1-(4-Fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid 97%
5g
$ 987.00

American Custom Chemicals Corporation
1-(4-FLUORO-BENZYL)-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 498.12

Total 3 raw suppliers

Chemical Property of 1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

Chemical Property:

PSA：59.30000
LogP:1.73390
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:247.06447134
Heavy Atom Count:18
Complexity:409

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 92% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN(C(=O)C(=C1)C(=O)O)CC2=CC=C(C=C2)F

Technology Process of 1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

There total 4 articles about 1-(4-Fluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 609-71-2
2-hydroxy-3-carboxypyridine

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 66158-41-6
1,2-dihydro-1-(4-fluorobenzyl)-2-oxopyridine-3-carboxylic acid

Guidance literature:: 2-hydroxy-3-carboxypyridine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-chloromethyl-4-fluorobenzene; In N,N-dimethyl-formamide; at 50 ℃; for 12h;

With sodium hydroxide; In water; for 4h; Reflux;
DOI:10.1016/j.ejmech.2018.05.019

Reference yield:

: 10128-91-3
methyl 2-hydroxynicotinate

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 66158-41-6
1,2-dihydro-1-(4-fluorobenzyl)-2-oxopyridine-3-carboxylic acid

Guidance literature:: methyl 2-hydroxynicotinate; 1-chloromethyl-4-fluorobenzene; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 8h;

With water; sodium hydroxide; In ethanol; at 85 ℃; for 0.5h;

Reference yield:

: 888721-12-8
methyl 1-(4-fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

: 66158-41-6
1,2-dihydro-1-(4-fluorobenzyl)-2-oxopyridine-3-carboxylic acid

Guidance literature:: methyl 1-(4-fluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylate; With sodium hydroxide; water; In methanol; at 65 ℃; for 1.5h;

With hydrogenchloride; In methanol; water; at 20 ℃; pH=1.0;
DOI:10.1021/jm800476q